ABCA1基因R1587K多态性在广西汉族与壮族人群中的分布  

ABCA1 Gene R1587K Polymorphism in Han Population and Zhuang National Minority

作　　者：李红艳[1] 黄健[1] 马义丽[1] 胡春萍[1] 黑木政秀[2] 于详远[1] 陈玲[1] 

机构地区：[1]桂林医学院生物化学与分子生物学教研室,广西桂林541004 [2]福冈大学生物化学系,日本福冈814-0180

出　　处：《广西师范大学学报（自然科学版）》2008年第4期120-123,共4页Journal of Guangxi Normal University:Natural Science Edition

基　　金：中日国际合作资助项目;广西高校百名中青年学科带头人资助计划项目(RC20060710016);广西科学基金(桂科基0448081)

摘　　要：为探讨ABCA1基因R1587K单核苷酸多态性(SNP)在中国广西汉族与壮族人群中的多态性分布,采用聚合酶链-限制性片段长度多态性(PCR-RFLP)技术,对无血缘关系的健康汉族人100例和壮族人84例的ABCA1基因R1587K位点进行检测,分析基因型频率和等位基因频率在2组人群中的分布,并与其他种族相比较。结果表明,ABCA1基因R1587K等位基因频率在汉族分别为ηR=0.475和ηK=0.525,壮族中分别为ηR=0.411和ηK=0.589;基因型频率在汉族分别为:ηRR=0.19,ηRK=0.57,ηKK=0.24,壮族分别为:ηRR=0.25,ηRK=0.32,ηKK=0.43。2组人群的基因型频率分布无显著性差异(P>0.05),2组人群在等位基因频率分布上也无统计学差异(P>0.05)。可见,ABCA1基因R1587K位点多态性在中国广西汉族与壮族的基因型频率分布无统计学差异,与国外不同种族人群相比具显著性差异。To investigate the distribution of ABCA1 gene R1587K polymorphism in the Han population and the Zhuang national minority in Guangxi China. The polymorphism of ABCA1 gene R1587K was determined by PCR-RFLP in 184 students including 84 healthy Zhuang people and 100 healthy Han people,X^2 test was used to compare the genotype and allele frequencies of Han population and the Zhuang national minority and Chinese population with those of other ethnic populations. The allele frequency of ABCA1 gene R1587K in Han population was as follows：ηR-0. 475,ηK=0. 525. The genotype frequency were as follows ： ηRR = 0. 19,7ηRK= 0. 57,ηKK= 0. 24 ; The allele frequency of the Zhuang national minority was as follows ：ηR=0. 411 ,ηK=0. 589 ,and the genotype frequency was as follows ：ηRR=0. 25,ηRK= 0. 32, ηKK= 0. 43;No significant difference was found in the frequency of ABCA1 gene R1587K genotype between Han population and Zhuang national minority in China. （P〈0.05）;No significant difference was found in the frequency of ABCA1 gene R1587K alleles between Han population and Zhuang national minority in China （P〈0. 05）. The frequency of ABCA1 gene R1587K genotype in Han population show no difference in comparison with from that of Zhuang national minority in Guangxi Autonomous Region of China,but significant differences is found when compared with different from Japanese or European population.

关 键 词：ABCAl基因 单核苷酸多态性(SNP) 汉族 壮族 

分 类 号：Q754[生物学—分子生物学]