大黄素对豚鼠结肠带平滑肌细胞钾通道活性的影响  

EFFECTS OF EMODIN ON THE ACTIVITY OF K CHANNELIN GUINEA PIG TAENIA COLI SMOOTH MUSCLE CELLS

作　　者：李俊英[1] 杨文修[1] 胡文卫 王津 金正根[1] 王新宇 许文胜[1] 

机构地区：[1]南开大学物理系生物物理教研室

出　　处：《药学学报》1998年第5期321-325,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：用检测平滑肌细胞电活动和张力技术，研究了大黄素对豚鼠结肠带平滑肌细胞电和收缩活动的影响并与ｃｒｏｍａｋａｌｉｍ，ｇｌｙｂｅｎｃｌａｍｉｄｅ，四乙胺及ＢａＣｌ２的作用进行比较。结果表明，大黄素加强平滑肌细胞电和收缩活动，作用效果与剂量有关；大黄素与ｃｒｏｍａｋａｌｉｍ的作用相互抑制。其促进平滑肌细胞电和收缩活动的作用与ｇｌｙｂｅｎｃｌａｍｉｄｅ相似，而与四乙胺和ＢａＣｌ２有明显区别。提示大黄素的作用机制与抑制细胞膜ＫＡＴＰ等钾通道的活性相关。The effects of emodin, cromakalim(KATP channel opener) glybenclamide(KATP channel inhibitor) Ba2+ and TEA on the electrical and contractive activites of the smooth muscle cells in guinea pig taenia coli and the relationship between emodin and four other drugs were studied by using intracellular microelectrode technique and the tension measuring technique. The results are as follows: (1)　Emodin enhances the electrical and contractive activities of the smooth muscle cells in guinea pig taenia coli.　The effects of emodin depend on its concentration. (2)　Emodin can resist the inhibition of cromakalim on the electrical and contractive activities of smooth muscle cells.　On the other hand, cromakalim was shown to suppress the effects of emodin. (3) Ba2+,　TEA and glybenclamide all can improve the electrical and contractive activities of smooth muscle cells and resist the inhibition of cromakalim. The effects of emodin were found to be similiar to that of glybenclamide but different from that of Ba2+　 and TEA. The results suggest that the mechanism of action of emodin is to inhibit the activity of KATP channel in the guinea pig taenia coli smooth muscle cells.

关 键 词：大黄素 结肠 平滑肌细胞 钾通道阻断剂 

分 类 号：R975[医药卫生—药品]