氯硝安定抗惊厥耐受及停药后脑内苯二氮类受体的变化  

Benzodiazepine receptors in amygdala kindled rats with tolerance to the anticonvulsant effect of clonazepam

作　　者：廖建湘[1,2] 王丽[1,2] 左启华[1,2] 

机构地区：[1]北京医科大学第一医院儿科 [2]广东省深圳市儿童医院

出　　处：《中华儿科杂志》1998年第5期286-289,共4页Chinese Journal of Pediatrics

摘　　要：目的探讨氯硝安定抗惊厥作用耐受性及依赖性的受体机理。方法采用放射自显影技术，观察了１１只完全点燃大鼠对氯硝安定抗惊厥作用耐受及停药后大鼠脑内苯二氮类受体的变化。结果大鼠耐受时某些脑区苯二氮类受体数目减少，而停药７天时，一些脑区受体数目增多。结论这种受体数目的变化可能与氯硝安定抗惊厥作用耐受性及依赖性有关。Objective To probe into the mechanisms of tolerance to the anticonvulsant effect of clonazepam. Methods The authors observed benzodiazepine receptors in amygdala kindled rats with tolerance to anticonvulsant effect of clonazepam by using autoradiography. Results With clonazepam tolerance decreased binding of benzodiazepine receptors to flunitrazepam was found in some brain regions, while on day 7 of clonazepam discontinuation the binding increased. Conclusion These changes may be responsible for the tolerance to and dependence on the anticonvulsant effect of clonazepam.

关 键 词：氯硝西泮 药物耐受性 药物依赖 受体 

分 类 号：R971.6[医药卫生—药品] R969.4[医药卫生—药学]