体育运动对轻度高血压病患者血胰岛素的影响  

The effects of physical exercise on serum insulin levels in patients with mild essential hypertension

作　　者：吴悦陶[1,2] 王觉生[1,2] 陈干仁[1,2] 王钟林[1,2] 伍汉文[1,2] 李炎升[1,2] 

机构地区：[1]湖南医科大学附属第二医院 [2]华西医科大学临床流行病培训中心

出　　处：《中华内科杂志》1998年第5期298-301,共4页Chinese Journal of Internal Medicine

基　　金：国际临床流行病学工作网(INCLEN)资助

摘　　要：目的探讨体育运动对高血压病患者血胰岛素的影响。方法将１０９例轻度原发性高血压病患者随机分配到运动组（５３例）和对照组（５６例）。两组均接受尼群地平降压治疗，同时对运动组进行为期３个月的中等强度运动干预。测量两组入选时和３个月后血压、空腹血糖、血胰岛素、血脂及口服葡萄糖负荷后１、２小时血糖及胰岛素。结果经过３个月规则运动，运动组空腹及糖负荷后１、２小时胰岛素水平低于对照组（Ｐ值均＜００５），其空腹胰岛素下降程度与运动量呈正相关（ｒ＝０６１，Ｐ＜００５），血胆固醇、甘油三酯及低密度脂蛋白水平低于对照组（Ｐ＜００５）。结论长期中等强度的体育运动能降低高血压病患者空腹及糖负荷后血胰岛素水平，并有利于纠正血脂代谢紊乱。Objective To determine the effects of physical exercise on serum insulin levels in hypertensives. Methods One hundred and nine patients with mild essential hypertension were randomly assigned to exercise group ( n =53) or control group ( n =56). Both groups were under nitrendipine regimen, but the intervention group underwent extra physical exercise of moderate intensity. The blood pressure, fasting serum lipids, blood glucose and insulin levels before and 1 hour and 2 hours after oral glucose loading were taken from each subject at entry and three months after the observation. Results There were significant decrease in insulin concentration at fasting, 1 hour and 2 hours after glucose loading in the exercise group ( P <0.05) after 3 months of exercise. The magnitude of decrease in fasting insulin levels correlated with the increase in amount of exercise ( r =0.61, P <0.01). In addition, exercise group experienced significant decrease in serum cholesterol, triglyceride, low density lipoprotein cholesterol ( P <0.05) as compared with the control group. Conclusion Regular physical exercise can decrease the insulin levels at fasting and after glucose loading and facilitate the control of dyslipidemia in essential hypertension.

关 键 词：体育运动 高血压 胰岛素 

分 类 号：R544.105[医药卫生—心血管疾病]