一锅法制备1-(2,3-二氯苯基)哌嗪盐酸盐  

One Pot Synthesis of 1-(2,3-Dichlorophenyl) Piperazinium Chloride

作　　者：朱晓斌[1] 徐崇福[1] 陈苗[1] 

机构地区：[1]江苏工业学院化学化工学院,江苏常州213164

出　　处：《江苏工业学院学报》2008年第4期32-35,共4页Journal of Jiangsu Polytechnic University

基　　金：江苏工业学院科技基金资助(ZMF05020022)

摘　　要：1-(2,3-二氯苯基)哌嗪盐酸盐是重要的医药中间体。以二乙醇胺为起始原料,无溶剂条件下经氯代反应制得β,β′-二氯代二乙基胺盐酸盐,不经分离直接滴加2,3-二氯苯胺和相转移催化剂,经环合反应合成目标化合物1-(2,3-二氯苯基)哌嗪盐酸盐。产率48.3%,纯度95.7%。讨论了各步反应的影响因素。产物经红外光谱、核磁共振氢谱分析验证与目标化合物的结构一致。该方法经济环保,省时,易操作。1-- （2, 3--Dichlorophenyl） piperazinium chloride is an important pharmaceutical intermediate. Diethanolamine was chlorinated without solvent to generate β, β＇--dichlorodiethylammonium chloride in situ, followed by addition of 2, 3--dichloroaniline and a phase transfer catalyst to cyclolize and yield the targeted compound 1-- （2, 3--dichlorophenyl） piperazinium chloride with 48.3% yield and 95. 7% purity. The structure of the product was consistent with that of the expected result by IR and NMR spectroscopy. The process applied was environment benign, time--saving and operation friendly.

关 键 词：1-(2 3-二氯苯基)哌嗪盐酸盐 一锅法反应 相转移催化剂 

分 类 号：O626.415[理学—有机化学]