常州市人群感染沙门菌和志贺菌血清型分布及耐药分析  

Analysis of serotype distribution and drug-resistance of Salmonella and Shigella infection in Changzhou

作　　者：钟学庆[1] 陈建英[1] 何梅芳[2] 何燕[1] 潘寒洁[1] 强洁[1] 

机构地区：[1]江苏省常州市天宁区疾病预防控制中心,江苏常州213021 [2]江苏省常州市第三人民医院,江苏常州213003

出　　处：《中国卫生检验杂志》2008年第12期2612-2615,共4页Chinese Journal of Health Laboratory Technology

基　　金：常州天宁区科学技术局基金资助项目(常天科[2007]08-11)

摘　　要：目的:了解常州市人群感染沙门菌和志贺菌的血清型分布和耐药性。方法:按国家标准和NCCLS推荐的K-B法对体检标本和临床标本检出的沙门菌和志贺菌进行血清分型和耐药性检测。结果:检出的沙门菌血清型中除临床标本中检出的较多的伤寒沙门菌外,德尔卑沙门菌、阿贡纳沙门菌、肠炎沙门菌和鸭沙门菌在两类标本都有较高的检出率;志贺菌都以B群居多,D群次之,B群中以福氏2 a型检出率最高,2b型次之。药敏试验显示沙门菌和志贺菌的耐药情况相当严重,且耐药产生迅速,多重耐药比较严重,两种细菌对复方磺胺甲恶唑、青霉素和四环素有严重的耐药性,其次是氨苄西林和呱拉西林,本次实验发现两种细菌对第三代头孢如头孢噻肟和头孢他定等也产生了一定的耐药性。Objective：To find out serotype distribution and drug-resistance of Salmonella and Shigella infection in Changzhou.Methods：We detected the serotype and drug-resistance of Salmonella and Shigella isolated from carriers and patients by K-B method according to national standard and NCCLS recommended.Results：There was high detectable rate of Salmonella serotype Derby.Salmonella serotype Agona,and Salmonella serotype Anatum,in both kinds of specimens except high detectable rate of Salmonella serotype Typhi in clinical specimens.Group B of Shigella was the most and Group D took second place.While S.flexneri 2a was detected mostly and 2b was the second.It showed that drug-resistance of Salmonella and Shigella was fairly serious through antimicrobial susceptibility test,and the situation was developing rapidly.Moreover,multiple drug-resistance was also serious.Both of the bacteria were highly resistant to Sulfamethoxazole,Penicillin and Tetracycline while a certain resistant to Ampicillin and Piperacillin.It find out that both bacteria are partly resistant to the third generation Cerhalosporins as Cefotaxime and Ceftazidime etc.

关 键 词：沙门菌 志贺菌 血清型分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]