引起HBVe系统双阳模式的另一种机制  

Another commonly mechanism causing simultaneous positive of HBeAg and HBeAb

作　　者：杜华[1] 谢闻悦[2] 贺柳杨[1] 赵田[1] 

机构地区：[1]解放军161医院,武汉430010 [2]广州军区广州总医院,广州510010

出　　处：《中国卫生检验杂志》2008年第12期2641-2642,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的：探讨HBV e系统双阳模式产生的一般性原因。方法：常规乙肝标志物免疫学检测筛选出61份e系统双阳模式血清样本,对每一份样本进行HBeAg RIA定量、前S1抗原检测以及HBV DNA荧光定量。结果：61份双阳模式血清的HBeAg RIA定量在1.5×105～2.1×105ng/ml区间内;前S1抗原检测54份阳性,阳性率88.5%;HBV DNA荧光定量全部阳性,平均拷贝数在107以上。结论：e系统双阳模式中的HBeAb为假阳性,双阳模式实为病毒高载量的表现,而不是血清转换。Objective：To discover the commonly mechanism causing simultaneous positive of HBeAg and HBeAb.Methods：A total of 61 serum samples with simultaneous positive of HBeAg and HBeAb were screened out by HBV ELISA routine.In each serum,concentration of HBeAg was measured by RIA,HBV DNA copies was quantitated by FQ-PCR and Pre-S1 antigcn was detected by sandwich immunoassay.Results：In 61 sera,the concentration of HBeAg was 1.5×105 to 2.1×105 ng/ml.Pre-S1 antigcn was detected in 54 sera and the positive rate was 88.5%.HBV DNA was positive in all 61 sera,the average of copies was above 107.Conclusion：The positive of HBeAb in pattern of simultaneous positive of HBeAg and HBeAb are usually false,and the pattern represents high load of virus,but not serum-transition.

关 键 词：乙型肝炎 双阳模式 假阳性 

分 类 号：R512.62[医药卫生—内科学]