2006～2007年通州区志贺菌检测与耐药性分析  

An analysis on test and antibiotic resistance in strains of Shigella isolated in Tongzhou District in 2006～2007

作　　者：卜丽薇[1] 唐一清[1] 周景林[1] 

机构地区：[1]北京市通州区疾病预防控制中心,北京101100

出　　处：《中国卫生检验杂志》2008年第12期2669-2670,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解通州区志贺菌菌型及对抗生素的耐药性,为细菌性痢疾的防治提供科学依据。方法:从60份腹泻病人粪便中检出志贺菌20株,采用国家标准检测方法进行生化鉴定、血清学分型和药物敏感试验。结果:阳性率33.33%,分别属于福氏志贺菌(B群)、宋氏志贺菌(D群)两个群6个血清型,其中以B群为主,14株占70.00%,D群次之,6株占30.00%。志贺菌对抗生素萘啶酸(NAL)、四环素(TET)、利福平(RFA)、复方新诺明(SMZ)、氨苄西林(AMP)高度耐药,耐药率均达90.00%以上,对氧氟沙星(OFX)高度敏感,敏感率达100.00%。结论:通州区志贺菌感染的优势菌型为福氏F4 c型为主,占35.00%,其次为宋内1相,占30.00%。应该合理使用抗生素,减少耐药现象。Objective：To have a better understanding of the strains of Shigella and antibiotic resistance in order to provide a scientific basis for the prevention and control of the bacterial dysentery.Methods：Tests on biochemical identification,serotyping and drug sensitivity of 20 strains of Shigella isolated from 60 patients with diarrhea were conducted based on national standard method.Results：The proportion of 13.3% was found positive,which were 14 prevailing strains of Sh.Flexneri（B group）,at the proportion of 70.00% and 6 strains of Sh.Sonnet（D group） at the proportion of 30.00% including 6 serological types.Shigella had a high degree of antibiotic resistance over the rate of 90.00% like NAL,tetracycline,rifampicin,sulfamethoxazole and ampicillin.Shigella was highly sensitive to ofloxacin at the rate of 100.00%.Conclusion：Sh.Flexneri 4c is the prevailing strain of Shigellae at the proportion of 35.00% in Tongzhou District,and Sh.Sonnet at the proportion of 30.00% is the sencondary.Antibiotics should be used properly to reduce the drug resistance.

关 键 词：志贺菌 血清学分型 耐药性 药物敏感试验 

分 类 号：R378.2[医药卫生—病原生物学]