北京市891例狂犬病疫苗接种后抗体水平分析  

Analysis of antibody level of 891 individuals after being inoculated rabies vaccine in Beijing

作　　者：杨洁[1] 和京果[1] 张铁钢[1] 陈萌[1] 王竞梅[1] 张雪春[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013

出　　处：《中国卫生检验杂志》2008年第12期2711-2712,2778,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:了解疫苗种类、免疫程序、采血时间、年龄、性别等因素对免疫效果的影响。方法:采用间接ELISA法对2007年北京市疾病预防控制中心免疫门诊采集到的检测狂犬病毒抗体的891份血清标本进行检测。结果:接种疫苗后抗体阳性率为92.7%,除性别因素外,年龄、接种疫苗的种类、免疫程序、采血时间均为血清抗体水平的影响因素。结论:绝大多数人群在接种狂犬病疫苗后可获得有效的保护,抗体阳转率在一定范围内随接种针次的增加而提高,严重咬伤者注射抗狂犬病血清后再进行全程免疫可获得满意的免疫效果。同时要注意采血时间对抗体检测结果也会产生影响。Objective：To investigate the impact of different vaccine varieties,procedure,sampling time,age,and sex on the immunization effect.Methods：The indirect ELISA method was used to detect the antibody level of 819 serums which were collected by Beijing CDC in 2007.Results：The positive rate of antibody against the rabies virus was 92.7%.Age,vaccine variety,procedure,and sampling time,except sex,were the affecting factors of antibody level in serum.Conclusion：Most of people can be protected after being inoculated the rabies vaccine.The positive rate increases together with the times of injection in a given range.The severe patient could get a satisfied immunizing effect after being injected antirabic serum and 5-dose rabies vaccine.The sampling time is an effect factor for the antirabic antibody detection.

关 键 词：狂犬病疫苗 抗体水平 免疫效果 

分 类 号：R186[医药卫生—流行病学]