多沙唑嗪与特拉唑嗪对原发性高血压患者心率变异性的影响  

Effect of Doxazosin and Terazosin on Heart Rate Variability in Patients With Primary Hypertension

作　　者：王莉[1] 华潞[1] 樊朝美[1] 孙兴昌[1] 何奇明[2] 庞会敏[1] 李一石[1] 

机构地区：[1]中国医学科学院北京济和医学院心血管病研究所阜外心血管病医院临床药理中心卫生部心血管药物临床研究重点实验室,北京市100037 [2]北京大学首钢医院首钢办公厅保健室

出　　处：《中国循环杂志》2008年第6期434-437,共4页Chinese Circulation Journal

摘　　要：目的:研究2类α1受体阻滞剂多沙唑嗪与特拉唑嗪对原发性高血压患者心率变异性的影响。方法:42例原发性高血压患者洗脱2周后,随机口服多沙唑嗪(n=21)2～4 mg/d或特拉唑嗪(n=21)2～4 mg/d,均每日1次服用,治疗8周。服药前后行24 h动态心电图检查各1次,分析24 h心率变异性时域和5 min心率变异性频域指标。结果:用药8周后高血压患者的24 h心率变异性时域指标:两组正常RR间期的标准差(SDNN)较用药前略有增加,相邻RR间期之差的均方根(rMMSD,特拉唑嗪组除外)、全部RR间期中相邻RR间期之差大于50 ms的心搏数除以总的RR间期个数乘以100(PNN50)较用药前轻度下降,但差异均无统计学意义;5 min心率变异性频域指标:低频(LF)、高频(HF)、低频与高频比值(LF/HF)与用药前比较差异无统计学意义。组间比较亦无统计学意义。结论:α1受体阻滞剂短期治疗未显示对高血压患者心率变异性的有益影响。Objective：To study the effects of two α1 blockers, doxazosin and terazosin, on heart rate variability （HRV）in patients with primary hypertension. Methods ：After 2 weeks drug-wash out, 42 patients with mild to moderate essential hypertension were divided in to two groups. Doxazosin group （ n = 21 ）, received doxazosin 2 - 4 mg per day （ once daily） for 8 weeks ; and Terazosin group （ n = 21 ）, received terazosin 2 -4 mg per day（ once daily）for 8 weeks as well. The 24-hour ambulatory ECG was performed before and after 8 weeks＇ treatment and the spectrum of HRV were analyzed. Results：After 8 weeks treatment,SDNN slightly increased in both groups, while rMMSD and PNN50 slightly decreased. LF, HF and LF/HF increased or decreased in mild degree without statistical meaning. The effect of doxazosin was similar to that of terazosin （ P 〉 0. 05 ）. Conclusion ：Two α1 blockers ,doxazosin and terazosin, showed no beneficial effect on HRV in patients with primary hypertension, this might be related to the decrease of blood pressure.

关 键 词：多沙唑嗪 特拉唑嗪 Α受体阻滞剂 原发性高血压 心率变异性 

分 类 号：R544[医药卫生—心血管疾病]