药物靶标热点领域的共词聚类分析研究  

Co-word clustering analysis for hot research areas of drug targets

作　　者：张音[1] 王松俊[1] 刁天喜[1] 楼铁柱[1] 

机构地区：[1]军事医学科学院卫生勤务与医学情报研究所,北京100850

出　　处：《中国新药杂志》2008年第23期2078-2080,共3页Chinese Journal of New Drugs

基　　金：国家863课题资助项目(2006AA02Z316)

摘　　要：后基因组时代的药物靶标是创新药物开发的源泉,了解药物靶标的热点领域有利于针对性地开展创新药物的研究工作。现对2003-2007年MEDLINE数据库收录的药物靶标文献的高频主题词进行共词聚类统计分析,并通过聚类映射图和战略坐标等分析结果与专业知识相结合,揭示药物靶标的热点领域。研究发现,目前的靶标研究主要聚焦在抗肿瘤领域,尤其是酶的药理学研究;结晶学、计算机模拟、生物模型等药靶开发技术也应值得重点关注。Drug targets in post-genomic era are the source of innovative drugs. The understanding of hot research areas of drug targets will benefit the development of targeted innovative drugs. In this article, we download the relevant documents from MEDLINE database and describe a co-word clustering analysis, in combination with clustering maps, strategic diagram and expertise to reveal the hot research areas of drug targets. The results show that the current studies are focusing on targets in the anti-tumor areas, particularly in the enzyme pharmacology. Drug target development technologies such as crystallography, computer simulation and biological models should also be paid close attention.

关 键 词：药物靶标 热点领域 共词聚类 

分 类 号：R95[医药卫生—药学]