杨梅素分散片的制备及性能考查  

Preparation and Characteristics of Myricetin Dispersible Tablets

作　　者：覃洁萍[1] 陈卫卫[1] 张炜[2] 许晨霞[2] 李伟[2] 

机构地区：[1]广西中医学院药学院,南宁530001 [2]广西中医学院

出　　处：《中国药师》2008年第12期1420-1424,共5页China Pharmacist

基　　金：广西科技厅资助项目(桂科能05112001-3)

摘　　要：目的：优化杨梅素分散片的处方，并对其相关性能进行考察。方法：首先以片剂外观和崩解时间为指标，初步筛选片剂基本处方，然后采用L9（3^4）正交试验设计法，以分散片的外观、体外溶出度及混悬性为指标，以综合评分法对处方进行优化，并采用紫外分光光度法分别对杨梅素分散片和普通片在不同时间内的溶出度进行了比较。结果：优化后的处方制得的分散片外观光洁。溶出度测定显示杨梅素分散片在15min和45min的溶出度分别达82．36％和93．14％，而杨梅素普通片在15min的累积溶出度仅为67．68％。结论：本制备工艺简单可行；杨梅素分散片与普通片相比，分散片起始溶出快，可较快地发挥药效作用。Objective： To optimize the formulation of myricetin dispersible tablets and inspect its characteristics. Method： The prescription of myricetin dispersible tablets was screened initially and optimized by orthogonal design, the appearance, the dissolution rate of the tablets and the suspension ability of the tablets solution were used as index. The dissolution rate were determined by ultraviolet spectrophotometry. Result： The dispersible tablets was fine in appearance. The dissolution rate was 80.36% and 93.14% in 15min and 45min respectively, but the dissolution rate of common myrieetin tablets was only 67.68% in 15min. Conclusion： The preparation is simple and feasible. The initial dissolution rate of dispersible tablets is faster than the common tablets.

关 键 词：杨梅素 分散片 处方 正交试验 溶出度 

分 类 号：R944.4[医药卫生—药剂学] R975.4[医药卫生—药学]