抗突变型瓜氨酸波形蛋白抗体 葡萄糖－6－磷酸异构酶和抗环瓜氨酸多肽抗体检测在类风湿关节炎诊断中的价值  

The diagnostic value of anti-mutated citrullinated vimentin, anti-cyclic citrullinated peptide and glucose-6-phosphateisomerase for rheumatoid arthritis

作　　者：武丽君[1] 路庆丽[1] 单新洁[1] 宋小芸[1] 孟新艳[1] 

机构地区：[1]新疆维吾尔自治区人民医院风湿免疫科,乌鲁木齐830001

出　　处：《中华风湿病学杂志》2009年第1期27-29,共3页Chinese Journal of Rheumatology

摘　　要：目的了解抗突变型瓜氨酸波形蛋白（MCV）抗体、葡萄糖-6-磷酸异构酶（GPI）、抗环瓜氨酸多肽（CCP）抗体检测在类风湿关节炎（RA）诊断中的价值。方法检测109例RA患者，24例其他风湿病患者及19名健康对照血清中抗MCV抗体、GPI和抗CCP抗体，比较3种抗体单独或联合检测对诊断RA的敏感性和特异性。结果RA组抗MCV抗体和GPI阳性率及平均浓度显著高于其他风湿病组及健康对照组（P〈0．05）。抗CCP抗体与GPI阳性率在RA患者中的差异有统计学意义。抗MCV抗体对RA敏感性最高（99．1％）；抗CCP抗体对RA特异性最高（90．7％）；联合检测以MCV＋CCP、MCV＋GPI以及MCV＋CCP＋GPI特异性最高（均为98．1％）。结论单独或联合检测抗MCV抗体、抗CCP抗体和GPI，有助于提高RA诊断的敏感性和特异性。Objective To investigate the diagnostic value of anti-mutated citrullinated vimentin （anti-MCV ） antibody, anti-cyclic citrullinated peptide （anti-CCP） antibodies and glucose-6-phospha-teisomerase （GPI） for rheumatoid arthritis （RA）. Methods Anti-MCV antibody, GPI and anti-CCP antibody were detected in serum samples of 109 RA patients, 24 non-RA rheumatic diseases patients and 19 healthy blood donors. The sensitivity and specificity of these parameters for the diagnosis of RA were analyzed. Results Both the positive rate and average cut off concentration of anti-MCV and GPI in RA were higher than those of non-RA rheumatic diseases or healthy controls （P〈0.05）. A significant difference was found between anti- MCV and GPI in RA patients. The most sensitive and specific parameter in RA was anti-MCV （99.1%） and anti-CCP （90.7%） respectively, but, when anti-MCV combined with anti-CCP, or GPI or anti-CCP and GPI, the specificity could be up to 98.1%. Conclusions Anti-MCV, anti-CCP and GPI alone or in combination may be valuable parameters for the diagnosis of RA.

关 键 词：关节炎 类风湿 抗突变型瓜氨酸波形蛋白抗体 抗环瓜氨酸麦肽抗体 葡萄糖-6-磷酸异构酶 

分 类 号：R686[医药卫生—骨科学]