Enhancement of memory function in aged mice by a novel derivative of xanomeline  

作　　者：Yihui Cui Dong Wang Wen Si Wen Lv Yan Niu Xiaoping Lei Yinhe Hu Xiaohua Cao 

机构地区：[1]Shanghai Institute of Brain Functional Genomics, The Key Laboratories of MOE and STCSM, East China Normal University,3663 Zhong Shan Road, Shanghai 200062, China [2]Peking University, School of Pharmaceutical Sciences, Beijing 100083, China

出　　处：《Cell Research》2008年第11期1151-1153,共3页细胞研究（英文版）

基　　金：This research was supported by the National Basic Research Program of China （973 Program） （NO2003CB716605） from the Ministry of Science and Technology, National Natural Science Foundation of China （NO30670682, NO30640068）, and grants from Shanghai Science and Technology Commission （05DJ14007, 06DZ19003）.

摘　　要：In age-related cognitive deficits and Alzheimer＇s disease （AD）, one of the most common pathological changes appears to be the loss of cholinergic neurons in the forebrain and the depletion of cortical cholinergic axons [1]. Accordingly, attempts have been made to generate therapies that aim to reverse the cognitive deficits associated with AD and aging by direct stimulation of mAChRs with specific agonists.

关 键 词：细胞 衰老 死亡 研究 

分 类 号：Q255[生物学—细胞生物学]