乙酰唑胺引起的脑血流变化对脑型氧中毒的影响  

Effects of dilating cerebral arierioles by actetazolamide on central nervous system oxygen toxicity

作　　者：黄俊龙[1] 肖翔[1] 刘昀[1] 蒋春雷[1] 

机构地区：[1]第二军医大学海医系,上海200433

出　　处：《中华航海医学与高气压医学杂志》2008年第6期332-335,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：第二军医大学联合攻关项目（200301）

摘　　要：目的观察乙酰唑胺引起的脑血流变化对脑型氧中毒的影响。方法腹腔注射乙酰唑胺并观察其对脑型氧中毒（central nervous system oxygen toxicity，CNS—OT）潜伏期的影响，测定腹腔注射乙酰唑胺后脑血流变化和脑组织氧化损伤状况，并观察对脑组织谷氨酸脱羧酶（GAD）含量的影响.结果腹腔注射乙酰唑胺显著缩短CNS—OT潜伏期（P〈0．05，P〈0．01），增加脑血流量（P〈0．01），加重脑组织氧化损伤，脑组织中的丙二醛（MDA）显著增多（P〈0．05），并减少GAD含量（P〈0．01）。结论腹腔注射乙酰唑胺通过扩张脑血管加重氧化损伤并减少GAD，进而促进急性氧中毒的发生.Objective To investigate effects of dilating ceretral arteriolesty acetazolamide on central nervous system oxygen toxicity （CNS-OT）. Methods In this study, latency to CNS-OT of rats with intraperitoneal injection of acetazolaimide, was determined and then cerebral blood flow and content of maleie dialdehyde （MDA） was measured, and also glutamie acid deearboxylase （GAD） was tested. Results CNSOT latency of rats which were injected with acetazolamide intraperitoneally was shortened significantly （ P 〈 0. 05, P 〈 0.01 ）. Acetazolamide could dilate the brain arterioles to increase the cerebral blood flow remarkably （P〈0.01）. The content of MDA of different brain area in groups treated with intraperitoueal injection of aeetazolamide increased significantly（P 〈 0.05）. And leuel of GAD in group treated with acetazolamide was reduced remarkably （P 〈 0.01 ）. Conclusions Acetazolamide shortened the latency to CNS-OT probably through its dilating cerebral arterioles to aggravate the oxidative damage and reduced content of GAD in brain. It could promote the incidence of acute oxygen poisoning.

关 键 词：高压氧 氧中毒 惊厥 脑血流 乙酰唑胺 

分 类 号：R5[医药卫生—内科学]