ICP-MS分析14种中药铀、钍、铊含量  

Determination of U,Th and Tl in Fourteen Chinese Traditional Medicines by Microwave Digestion-ICP-MS

作　　者：孙卫民[1] 薛大方[2] 李红[1] 刘辉[1] 滕文锋[1] 

机构地区：[1]大连医科大学检验医学院,辽宁大连116044 [2]辽宁出入境检验检疫局技术中心,辽宁大连116000

出　　处：《光谱学与光谱分析》2009年第1期256-258,共3页Spectroscopy and Spectral Analysis

基　　金：辽宁省教育厅高等学校科学研究项目(990221063)资助

摘　　要：微量元素尤其是有害元素的监测控制与中药质量密切相关。对14种肿瘤治疗常用中药用微波消解法进行处理,用电感耦合等离子体质谱（ICP-MS）法检测了其中铀、钍和铊的含量。结果显示14种中药中铀、钍和铊含量的变化范围分别为,铀,0.005153-0.1534μg·g^-1;钍,0.03501-0.4628μg·g^-1;铊,0.00143-1.600μg·g^-1。铀、钍和铊的含量都较低,但个体含量差异较大。采用统计软件SPSS11.5对结果进行分析比较,结果显示清热解毒类中药与以毒攻毒类中药中铀、钍和铊含量都无显著性差异;植物类药与动物类药中铀、钍和铊的含量也无显著性差异。ICP-MS法快速、灵敏、准确,可作为中药中铀、钍和铊含量分析的可靠方法,另一方面本研究结果为临床中药的安全使用和药物开发提供了参考数据。Fourteen Chinese traditional medicines were digested by microwave digestion,which are generally applied to treat tumor in clinic,and the contents of U,Th and Tl in the fourteen Chinese traditional medicines were determined by inductively coupled plasma mass spectrometry（ICP-MS）,and the results show that the change ranges of the elements contents were： 0.005 153-0.153 4 μg·g^-1 for U;0.035 01-0.462 8 μg·g^-1 for Th;0.001 43^-1.600 μg·g^-1 for Tl.The contents of U,Th and Tl in the fourteen Chinese traditional medicines were low,and not with one accord.The determination results of the fourteen Chinese traditional medicines were analyzed by SPSS 11.5,and the results show that there were not significant deviations（p〉0.05） of the contents of U,Th and Tl between the medicine of treating the toxifying disease with poisonous agents and the medicines of heat-clearing.The study indicates that inductively coupled plasma mass spectrometry（ICP-MS） is a quick,accurate,sensitive method to determine the contents of U,Th and Tl in Chinese traditional medicine,and the results of this study provide reference data for using Chinese traditional medicine safely in clinic and developing Chinese traditional medicine.

关 键 词：微波消解 电感耦合等离子体质谱(ICP-MS) 中药 铀 钍 铊 

分 类 号：O657.3[理学—分析化学]