新生儿窒息血浆内皮素及降钙素基因相关肽的变化  

CHANGES IN PLASMA CONCENTRATIONS OF ENDOTHELIN AND CALCITONINGENERELATED PEPTIDE IN NEWBORNS WITH ASPHYXIA

作　　者：郭在晨[1] 王东红[1] 王颖[1] 黄丽英[1] 

机构地区：[1]北京医科大学第一医院儿科

出　　处：《北京医科大学学报》1998年第1期57-58,66,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：探讨新生儿窒息血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）及降钙素基因相关肽（ｃａｌｃｉｔｏｎｉｎｇｅｎｅｒｅｌａｔｅｄｐｅｐｔｉｄｅ，ＣＧＲＰ）的变化。方法：对２４例足月新生儿窒息患儿及１８例对照新生儿，用放射免疫学方法测定出生后第１天和第５天血浆ＥＴ１及ＣＧＲＰ浓度。结果：生后第１天窒息患儿血浆ＥＴ１及ＣＧＲＰ水平均显著高于对照组；生后第５天患病组二者水平显著下降。实验组第１、５天血浆ＥＴ１及ＣＧＲＰ呈正相关性。结论：新生儿窒息血浆ＥＴ生成增加可能起着损伤机体的作用；而ＣＧＲＰ升高可能是机体的自我保护机制。Objective: To investigate the changes in plasma concentrations of endothelin (ET)and calcitonin generelated peptide (CGRP) in fullterm newborns with asphyxia. Methods: Plasma levels of ET1 and CGRP was measured in 24 fullterm newborns with asphyxia and 18 controls on the first and fifth days after birth by using radioimmunoassay. Results: Both plasma ET and CGRP levels of asphyxiated newborns were significantly increased as compared with those of controls on the first day after birth. They were obviously low on day 5 after birth. There was no significant difference either in plasma level of ET or in plasma level of CGRP between day 1 and day 5 after birth in control newborns. In the newborns with asphyxia, a positive correlation between plasma ET and CGRP levels was observed. Conclusion: The results of this study suggest that in newborns with asphyxia, the ET production is increased, which may yield scathing effect on the newborns, while the increase in plasma CGRP level is probably involved in a mechanism responsible for a selfprotection of the body.

关 键 词：新生儿窒息 血浆 内皮素 CGRP 

分 类 号：R722.12[医药卫生—儿科]