倍他洛尔对中国高血压病人降压疗效及安全性观察  

ANTIHYPERTENSIVE EFFECTS AND SAFETY OF BETAXOLOLIN CHINESE HYPERTENSIVE PATIENTS

作　　者：陈红[1] 徐成斌[1] 胡恒慧[1] 陈源源[1] 郑俐慧[1] 

机构地区：[1]北京医科大学人民医院心内科

出　　处：《北京医科大学学报》1998年第1期61-63,共3页Journal of Peking University(Health Sciences)

摘　　要：目的：评价倍他洛尔（ｂｅｔａｘｏｌｏｌ）对中国轻、中型原发性高血压病人的短期降压疗效及安全性。方法：７６例轻、中型高血压病病人。其中诊室血压组６３人，用随机双盲法观察服倍他洛尔４周后血压的变化及副作用；动态血压组１３人，用随机单盲法观察服倍他洛尔前后２４ｈ动态血压的变化。结果：倍他洛尔的降压作用可持续２４ｈ。４周总的降压有效率为８０．６％。药物的谷／峰比值大于５０％。４周内未发现明显的副作用。结论：中国轻、中型高血压病病人短期使用倍他洛尔（１０～２０ｍｇ／ｄ）降压安全、有效。Objective: To assess the antihypertensive effects and safety of betaxolol in Chinese patients with mild to moderate essential hypertension. Methods: 76 patients with mild to moderate essential hypertension were investigated. 63 patients of them were randomized (doubleblind) to receive either betaxolol　(n=31,10～20　mg once daily)　or bisoprolol　(n=32,5～10　mg once daily) for 4 weeks to observe the change of clinic blood pressure(BP) and side effects. In the remaining patients(n=13),ambulatory blood pressure monitoring(ABPM) was performed by randomized singleblind method. Results: Blood pressure control can cover over 24 hours in betaxolol group. In the fourth week, normotension was achieved 80.6% of patients given betaxolol. The average dose for response is 10 mg. The trough to peak ratios for systolic and diastolic blood pressures by betaxolol were all more than 50%. There are no side effects within 4 weeks. Conclusion: Oncedaily dosing of betaxolol(10～20 mg) is effective and safe to Chinese hypertensive patients with mild to moderate essential hypertension within a 4week treatment period.

关 键 词：高血压 药物疗法 倍他洛尔 降压药 疗效 

分 类 号：R972.4[医药卫生—药品] R544.105[医药卫生—药学]