(E)-1-二苯甲基-4-[3-(3,4-二羟苯基)-2-丙烯基]哌嗪(Ⅰ)的合成及其SOD样活性测定  

Synthesis of (E)1diphenylmethyl4[3(3,4dihydroxy phenyl)2propenyl] piperazine and determination of SODlike activity

作　　者：吴红[1] 骆文博[1] 王多宁[1] 

机构地区：[1]第四军医大学基础部化学教研室

出　　处：《第四军医大学学报》1998年第1期101-102,共2页Journal of the Fourth Military Medical University

摘　　要：目的和方法：为了研究心血管类药物的构效关系，用二苯甲基哌嗪和咖啡酸为原料，经缩合、还原等反应制得标题物（Ｉ）；并通过黄嘌呤黄嘌呤氧化酶鲁米诺化学发光体系检测了其清除Ｏ·２自由基的作用．结果和结论：经元素分析、红外光谱和核磁共振谱测定，合成物（Ｉ）与结构相符，收率７２．５％；化学发光法检测显示出较强的ＳＯＤ样活性，具有较强的抗自由基作用．Aim and Methods: To develop new medicine, we took diphenylmethyl piperazine and caffeic acid as materials, making objective compound (I) by condensation and reduction reaction, etc. At the same time, we detected this compound (I) to scavenge O·2 free radical through XanthineXanthine OxidaseLuminol Chemiluminescence system. Results and Conclusion: Through elementary analysis and the detection of IR and ′HNMR spectra, results indicated the compound (I) could accord with its constitution, yield rate was 72.5% . Chemiluminescence detection indicated that it (I) had strong SODLike activity and antifree radical role. 

关 键 词：哌嗪 合成 SOD活性 测定 心血管药 

分 类 号：TQ463.5[化学工程—制药化工] R972[医药卫生—药品]