胶束动电毛细管色谱法分离测定复方感冒药帕尔克中的4种组分  

Separation and Determination of Four Ingredients in Cold Medicine Pa-er-ke by Micellar Electrokinetic Capillary Chromatography

作　　者：纪松岗[1] 柴逸峰[1] 吴玉田[1] 梁东升[1] 许自明[1] 李晓 

机构地区：[1]第二军医大学药学院

出　　处：《药物分析杂志》1998年第3期170-173,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：胶束动电毛细管色谱法分离测定复方感冒药帕尔克中的扑热息痛、扑尔敏、苯丙醇胺和右美沙芬４种组分。通过对缓冲液ｐＨ和ＳＤＣ浓度的优化选择，确定分离用缓冲液为２０ｍｍｏｌ／Ｌ硼酸—２０ｍｍｏｌ／Ｌ氢氧化钠溶液（ｐＨ１０，含５０ｍｍｏｌ／ＬＳＤＣ），在９ｍｉｎ内将上述４种组分完全分离且其迁移时间具有良好的重现性。A micellar electrokinetic capillary chromatographic method was set up to separate and determine four ingredients(including chlopheniramine,paracetamol,phenylpropanolamine and dextromethophane).Optimization of pH and SDC concentrations of buffer solution was studied,which showed that 20m mol/L H3BO3-20m mol/L NaOH(pH10) with 50m mol/L SDC could separate the above ingredients completely within 9min with good reproducibility of migration times.Using caffeine as internal standard,the four ingredients in tablet of Pa-er-ke were determined.

关 键 词：胶束动电 毛细管色谱 扑热息痛 扑尔敏 苯丙醇胺 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]