1023合剂对实验性口腔癌的抑瘤及阻癌的正交实验研究  

The orthogonal design study on tumor inhibition and cancer block role of Chinese medicinal 1023 co.

作　　者：陈作良[1,2] 官玉芹[1,2] 陈汉正[1,2] 陈新民 

机构地区：[1]湖北医科大学口腔医学院 [2]厦门卫校口腔医院

出　　处：《中华口腔医学杂志》1998年第1期50-52,共3页Chinese Journal of Stomatology

摘　　要：目的寻找一种防止口腔癌前损害癌变的药物。方法用１０２３合剂（由黄芪、绞股蓝、川芎和含硒绿茶组成）对仓鼠颊囊的实验性口腔癌前损害和癌进行了抑瘤、阻癌研究，在对动物涂擦二甲基苯蒽（ＤＭＢＡ）的同时，用１０２３中药合剂灌胃。结果１０２３合剂用药组的仓鼠肿瘤的发生比对照组推迟了１２天；其异常增生和癌的发生率明显低于对照组（Ｐ＜０．０１）。结论１０２３合剂确有抑瘤、阻癌功效。通过正交实验分析发现，其抑瘤、阻癌的最佳配方为Ａ２Ｂ２Ｃ２Ｄ１。Objective To study the effect of Chinese herb medicine on the inhibition of tumor formation and block of malignant transformation. Methods The Chinese medicine 1023 co. was given by intubation feeding started simultaneously with the painting of 0.5% DMBA on the hamster′s cheek mucosa. Results The tumor formation in 1023 co. group was delayed for 12 days comparing with the control group and the incidence of dysplasia and cancer in 1023 co. group was lower significantly than that of the control group ( P <0 01).Conclusion The 1023 co. is effective in inhibiting tumor formation and blocking cancerous transformation. By orthogonal design we find the proper prescription is A 2 B 2 C 2 D 1.

关 键 词：1023合剂 口腔癌 抑癌试验 中医药疗法 

分 类 号：R273.98[医药卫生—中西医结合]