云南南部恶性疟原虫对咯萘啶敏感性的纵向监测  

LONGITUDINAL SURVEILLANCE OF SENSITIVITY OF PLASMODIUM FALCIPARUM TO PYRONARIDINE IN SOUTH YUNNAN *

作　　者：杨恒林[1,2] 刘德全[1,2] 黄开国[1,2] 张春勇[1,2] 李春富[1,2] 

机构地区：[1]云南省疟疾防治研究所 [2]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1998年第2期81-83,共3页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：卫生部青年科学基金

摘　　要：目的：了解恶性疟原虫对咯萘啶敏感性的变化，以指导合理用药。方法：采用ＷＨＯ体内四周法及体外微量测定法，在云南南部勐腊县进行敏感性纵向监测。结果：１９８４－１９８５年和１９９５年体内观察分别为３６例和３９例，其平均退热时间分别为３２．７ｈ±１６．０ｈ和５６．２ｈ±２７．４ｈ。无性体转阴时间分别为６４．２ｈ±２２．９ｈ及５５．３ｈ±１１．８ｈ。复燃率分别为１５．２％（５／３３）和３７．５％（９／２４）。１９８８、１９９０、１９９２和１９９５年体外测得ＩＤ５０分别为１３．０ｎｍｏｌ／Ｌ、２０．０ｎｍｏｌ／Ｌ、３２．０ｎｍｏｌ／Ｌ和４０．０ｎｍｏｌ／Ｌ。ＩＤ９５依次为４８．０ｎｍｏｌ／Ｌ、１３６．０ｎｍｏｌ／Ｌ、３２５．０ｎｍｏｌ／Ｌ和３３０．０ｎｍｏｌ／Ｌ。抗性率分别为０、８．８％、１３．８％及３６．４％。结论：当地恶性疟原虫对咯萘啶的敏感性呈下降趋势。AIM: To understand the changes in the sensitivity of Plasmodium falciparum to pyronaridine in the south of Yunnan Province. METHODS: WHO standard in vivo and in vitro microtest was used. RESULTS: In 1984-1985 and 1995, 36 and 39 cases of acute falciparum malaria were observed, the average defervescence time being 32 7±16 0 h and 56 2±27 4 h, the mean asexual parsite clearance time, 64 2±22 9 h and 55 3±11 8 h, and the recrudescence rate of patients followed up for 28 days, 15 2%(5/33) and 37 5%(9/24), respectively. The resistance rates of resistant isolates by in vitro microtest were 0(0/24), 8 8%(3/34), 13 8%(4/29) and 36 4%(4/11) in 1988, 1990, 1992 and 1995, respectively, while the corresponding ID 50 were 13 0, 20 0, 32 0 and 40 0 nmol/L, ID 95 were 48 0, 136 0, 325 0 and 330 0 nmol/L, the mean concentrations for complete inhibition of schizont formation were 32 6, 99 5, 148 2 and 190 1 nmol/L, respectively. CONCLUSION: The sensitivity of Plasmodium falciparum to pyronaridine was found to have a tendency of continuous dropping in south Yunnan.

关 键 词：疟疾 疟原虫 敏感性 咯萘啶 监测 

分 类 号：R531.3[医药卫生—内科学]