多囊卵巢综合征患者血栓调节蛋白水平变化的研究  

Study on change of thrombomodulin in patients with polycystic ovary syndrome

作　　者：李巍巍[1] 唐海燕[2] 

机构地区：[1]郑州大学第三附属医院生殖中心,450052 [2]郑州大学第一附属医院

出　　处：《中国妇产科临床杂志》2009年第1期49-51,共3页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的通过检测多囊卵巢综合征(PCOS)患者血清血栓调节蛋白(TM)的水平变化,探讨TM与PCOS发生血管病变的关系。方法选择PCOS患者80例为研究组,其中胰岛素抵抗(IR)组43例和非IR组37例,正常妇女30例为对照组,采用酶联免疫吸附法检测血清TM水平;生化法检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FSG)、载脂蛋白A1(ApoA1)和载脂蛋白B(ApoB);放射免疫法检测内分泌激素和空腹胰岛素(FINS)。结果非IR组、IR组TM水平与对照组比较,差异有显著性(P<0.05),非IR组和IR组TG、ApoB高于对照组(P<0.01),而HDL-C、ApoA1低于对照组(P<0.01)。结论伴胰岛素抵抗的PCOS患者TM水平增高,可能与其发生血管病变有关。Objective To investigate the change of thrombomodulin （TM） in polycystic ovary syndrome （P- COS） and explore the relationship between the molecular markers of endothelial dysfunction and vasculopathy of PCOS. Methods A total of 80 women with PCOS, including 43 with insulin resistance （IR） and 37 without, and 30 health women were recruited in this study. TM was measured by ELISA, and total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL - C）, low density lipoprotein cholesterol （LDL-C）, apolipoprotei- nA - 1 （ApoA1）, ApoB and fasting serum glucose （FSG） were measured. Serum reproductive hormones and fasting insulin （FINS） were measured by radioimmunoassay. Results TM was higher in IR group and non - IR group than in the control group （P〈0. 05）. Higher TG and lower HDL- C were found in IR group and non- IR group comparing to the control （both P〈0. 01）. Conclusion The increased TM might play a role in vasculopathy in patients with IR PCOS.

关 键 词：多囊卵巢综合征 血栓调节蛋白 胰岛素抵抗 心血管疾病 

分 类 号：R711.75[医药卫生—妇产科学]