过氧化物增殖体激活受体与肺部疾病  

Peroxisome proliferator-activated receptors and lung diseases

作　　者：肖波[1] 王建春[1] 

机构地区：[1]第三军医大学新桥医院全军呼吸内科研究所,重庆400037

出　　处：《医学研究生学报》2009年第1期79-82,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金资助项目(批准号:30570808)

摘　　要：过氧化物增殖体激活受体(PPAR)属非类固醇激素类核受体,参与脂类代谢、炎症反应等多种生理和病理活动的调节。现就PPAR的结构、活化机制、配体及其在肺部常见疾病中可能的作用机制进行综述,并介绍其临床应用前景。Peroxisome proliferator-activated receptors （PPAR） belong to the nuclear hormone receptor family. They have been implicated as important regulators of various physiological processes, such as lipid and lipoprotein metabolism and inflammation. This article reviews the structure of PPARs, their activity regulation and ligands and their correlation with lung diseases.

关 键 词：过氧化物增殖体激活受体 配体 肺部疾病 

分 类 号：R563[医药卫生—呼吸系统]