革兰氏阴性杆菌氟喹诺酮耐药株的实验研究  

THE EXPERIMENTAL STUDY OF FLUOROQUINOLONES RESISTANT STRAINS IN GRAM NEGATIVE BACILLI

作　　者：林健梅[1] 范昕建[1] 冯萍[1] 吕晓菊[1] 周仲辉 张慧琳[1] 卢毅[1] 

机构地区：[1]华西医科大学传染科 [2]四川省人民医院传染科

出　　处：《中国微生态学杂志》1998年第1期21-23,共3页Chinese Journal of Microecology

基　　金：国家自然科学基金

摘　　要：对８２株临床分离的氟喹诺酮药物（Ｆｌｕｏｒｏｑｕｉｎｏｌｏｎｅｓ，ＦＱＮＳ）耐药菌进行了多种抗生素敏感试验。结果显示８２株耐药菌对５种药物耐药率分别为：诺氟沙星９７．５６％、依诺沙星９６．３４％、罗美沙星９５．１２％、氧氟沙星９２．６８％、环丙沙星８７．８％。３２株菌对ＦＱＮＳ存在较普遍的交叉耐药现象，对氨苄青霉素、庆大霉素、丁胺卡那霉素及头孢菌素类的多重耐药率也较高。８２株菌中有４３株菌携带质粒（５２．４４％）。质粒消除及转化实验结果表明：质粒与ＦＱＮＳ耐药性无关。A study was taken to evaluate the susceptibility patterns of Gram negative bacilli(82 Strains) isolated from patients. All of the strains,which include E. coli(65 strains),P.aeruginosa(7 strains), E. cloacal(4 strains).Ac. anitratum(3 strains),P.vulgaris(l strain),K.Pneurmoniae (1 strain), and A. faecalis (1 strain),were studied for suscepitibility to five kinds of fluoroquinolones(FQNS), ampicillin (Amp), gentamycin(GM), amikacin(AMK), cefoperazone(CPZ),cefazilin (CEZ),imipenem(IMP) by a tube dilution method,The result showed that the rates of resistance to norloxacin (NFLX) was 97.5%, enoxacin(ENX) 96.34%,lomefloxacin (LMLX) 95.2%, ofloxacin(OFLX) 92.68%,and ciprofloxacin(CPLX) 87.8%,respectively.Cross-resistances to five kinds of FQNS exist extensively.Plasmid profile showed that 43 strains include plasmids (52.44%) and no FQNS resistant plasmid was detected.

关 键 词：革兰氏阴性杆菌 氟喹诺酮 多重耐药性 耐药株 

分 类 号：R978.19[医药卫生—药品] R378[医药卫生—药学]