2型糖尿病病因的治疗及并发症预防  

Therapy and Complication Prevention of Type 2 Diabetes

作　　者：白嘉祥[1] 

机构地区：[1]天津市天津医院内科

出　　处：《医学综述》2009年第3期452-454,共3页Medical Recapitulate

摘　　要：治疗2型糖尿病的病因是防止合并症发生的关键。氧化应激、β细胞凋亡、炎性因子等是2型糖尿病发生的病因，也是并发症的共同发病途径。高糖、高脂状态增加活性氧簇，减弱抗氧化能力，使机体发生一系列病理改变。这些异常状态引起β细胞凋亡大于复制与新的B细胞产生，导致β细胞不可逆的减少，形成恶性循环。炎性因子学理论认为，2型糖尿病是一种自然免疫和低度炎症性疾病。一些相关的药物可改善其病因，应用于临床治疗糖尿病及防止并发症发生。The etiological treatment for type 2 diabetes is the key to prevent its complications. Many factors are the etiology of type 2 diabetes, as well as the common pathway of its complication, such as oxidative stress, β-cell apoptosis,inflammation and so on. The high-glucose and hyperlipidemia can increase reactive oxygen species, suppress the anti-oxidative capacity,and then result in a series of pathological changes. These abnormities cause more β cells apoptosis than β-cell replication and new β cells production, and then lead to a vicious cycle of irreversible reduction of β cells. In cytokines theories,type 2 diabetes is a disease with natural immune and minor inflammatory. Some related drugs could improve its etiology,and could be applied in clinical treatment for this disease and prevention of its complication.

关 键 词：2型糖尿病 病因治疗 氧化应激 Β细胞凋亡 炎性因子 

分 类 号：R587.1[医药卫生—内分泌]