羟丙基壳聚糖纳米微球的制备及其缓释效果  

Preparation of Hydroxypropyl-chitosan Nanospheres and Their Controlled Release in vitro

作　　者：谢宇[1] 尚晓娴[1] 颜流水[1] 

机构地区：[1]南昌航空大学材料化学系,南昌330063

出　　处：《应用化学》2009年第2期193-197,共5页Chinese Journal of Applied Chemistry

基　　金：江西省自然科学基金(0620071)资助项目;江西省教育厅科技项目(赣教技字[2007]168号);航空高校科研基金(EA200502138)资

摘　　要：由壳聚糖与环氧丙烷制备了取代度为0.46的羟丙基壳聚糖(HCS)。将其配制成水溶液,利用离子凝胶法与多聚磷酸钠(TPP)反应,形成形状规整、粒径在100～300 nm可控的羟丙基壳聚糖纳米微球,以牛血清蛋白(BSA)为模型药物,考察了其缓释效果。结果显示,最大包封率达86%,载药量为46%,在缓释初期2 h内平均释放药量的28%,后期均呈现缓慢释放。Hydroxypropyl-chitsoan（HCS） with a substitution degree of 0.46 was prepared. Hydroxypropyl-chitosan nanospheres with the particle size of 100 -300 nm were formed when hydroxypropyl-chitosan water solution reacts with sodium polyphosphate based on ion gel method. TEM micrograph reveals that the morphology of hydroxypropyl-chitosan nanospheres was regular. Bovine Serum Albumin （BSA） was taken as the typical drug to determine the controlled release in vitro. The result suggests that the highest encapsulation efficiency and load of BSA reached to 86% and 46% respectively. The HCS nanospheres released 28% of BSA in average within 2 h, and it continuously release the entrapped protein, but with a slower rate.

关 键 词：壳聚糖 羟丙基 纳米微球 牛血清蛋白 缓释 

分 类 号：O629[理学—有机化学]