两亲嵌段共聚物的合成及纳米自组装  

Synthesis and Self-Assembly of Amphiphilic Triblock Copolymers

作　　者：黄宝铨[1] 

机构地区：[1]福建师范大学化学与材料学院,福建福州350007

出　　处：《高分子材料科学与工程》2009年第1期1-4,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20604007);福建省科技重点项目(2007I0013);福建省自然科学基金资助项目(2008J0078)

摘　　要：首先用苄氧羰基赖氨酸和三光气反应合成苄氧羰基赖氨酸酸酐,然后将聚乙二醇中活性较弱的羟基转化为氨基,最后以双端氨基聚乙二醇作为引发剂,采用阴离子开环聚合合成了聚(Nε-苄氧羰基赖氨酸)-聚乙二醇-聚(Nε-苄氧羰基赖氨酸)(PLL(Z)-PEG-PLL(Z))。PLL(Z)-PEG-PLL(Z)经去保护后得到带正电荷的聚赖氨酸-聚乙二醇-聚赖氨酸(PLL-PEG-PLL)。PLL(Z)-PEG-PLL(Z)在水溶液中自组装形成的聚集体类似于纳米多孔聚集体结构,具有疏松的空洞,原子力显微镜观测其呈球形,其大小为220 nm左右。A novel amphiphilic triblock copolymers which consist of poly（ethylene glycol） （PEG） and poly（ε- （benzyloxycarbonyl）-Lysine PLL（Z） were synthesized by anion ring opening polymerization of N-carboxyanhydride of N^t- （benzyloxycarbonyl）-L- Lysine （Lys（Z）-NCA） using α-amino-ω-amino-poly（ ethylene glycol） as the initiator in dimethylformamide（DMF）. Then, poly （L-Lysine）-poly （ethylene glycol） -poly （L-Lysine） （PLL-PEG-PLL） was obtained by removing the protecting groups. The blocks were characterized by infrared spectroscopic （IR）, hydrogen nuclear magnetic resonance spectrum （^1H-NMR）. The results show that the block copolymers are of well defined structure The self-assembled behaviors of PLL （Z）-PEG-PLL （Z） in aqueous medium were investigated and aggregates morphology of triblock copolymer were observed by atom force microscopy. The results show that PLL （Z）-PEG-PLL（Z） forms hollow sphere aggregates with an average diameter at 220 nm. This regular nanometer structure has potential applications in biomedicine.

关 键 词：两亲嵌段共聚物 聚合物纳米粒子 自组装 

分 类 号：TB383[一般工业技术—材料科学与工程]