聚天冬氨酸交联温敏性水凝胶的药物缓释性能  

Releasing Property of the Thermoresponsive Hydrogels Cross-Linked with Polyaspartic Acid for Drug Delivery System

作　　者：于跃芹[1] 常宪智[1] 田红杰[1] 许洋[1] 

机构地区：[1]青岛科技大学化学与分子工程学院,山东青岛266042

出　　处：《高分子材料科学与工程》2009年第1期79-82,共4页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(20476049);山东省自然科学基金资助项目(Y2006B10)

摘　　要：选用牛血清蛋白(BSA)和5-氟尿嘧啶(5-FU)为模型药物,以聚天冬氨酸交联温敏性水凝胶为载体材料,采用包埋法制备了载药水凝胶,研究了水凝胶的载药和释药性能。水凝胶对BSA和5-FU的包埋率均大于98%。37℃时,水凝胶中丙烯酸用量越大,BSA的释放率越低;交联剂用量对BSA的释放率无显著影响。25℃时,丙烯酸用量越大,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。37℃时,丙烯酸用量越小,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。A preliminary study of the thermoresponsive hydrogels cross-linked with polyaspartic acid for drug delivery system was performed with model drugs of 5-fluorouracil （5-FU） and bovine serum albumin （BSA）. It is found that the releasing rate and cumulative quantity of BSA decrease with the increase of acrylic acid （AAc） content at 37℃; in PBS, and cross-linker content has little effect on the BSA releasing rate. The releasing rate and cumulative quantity of 5-FU increase with the increase of AAc content, and decrease with the increase of cross-linker content at 25℃; in PBS, while the releasing rate and quantity of 5-FU decrease with increasing AAc content and cross-linker content in the hydrogels at 37 ℃ in PBS.

关 键 词：温敏性水凝胶 药物缓释 5-氟尿嘧啶 牛血清蛋白 

分 类 号：TB381[一般工业技术—材料科学与工程]