嘧啶氧磷毒性和解毒试验研究  

Studies on the Toxicity and Detoxication of N23

作　　者：王茂风[1] 杨泗溥[2] 朱慧香[2] 

机构地区：[1]辽宁大学生物系 [2]化工部农药安全评价监督检验中心

出　　处：《辽宁大学学报（自然科学版）》1998年第2期147-150,共4页Journal of Liaoning University：Natural Sciences Edition

摘　　要：本文报道了嘧啶氧磷（代号为Ｎ２３）的急性经口、经皮毒性和解毒试验研究结果．嘧啶氧磷对小白鼠经口ＬＤ５０为８７ｍｇ／ｋｇ，大白鼠经口ＬＤ５０为１８３ｍｇ／ｋｇ，大白鼠经皮ＬＤ５０为１０６２ｍｇ／ｋｇ。The toxicity and detoxication of N23, an organophosphorus insecticide, were studied in mice and rats. Oral LD 50 of the compound was 87 mg/kg to mice, 183mg/kg to rats. Its dermal LD 50 was 1062mg/kg to rats. The results of detoxication test shown that 2 pam chloride (2 pyridinealdoxime methochloride was efficacious antidote for mice treated by N23.

关 键 词：嘧啶氧磷 解毒 毒性 有机磷杀虫剂 

分 类 号：TQ453.22[化学工程—农药化工] R595.4[医药卫生—内科学]