氨甲苯酸注射液与盐酸莫西沙星氯化钠注射液配伍的稳定性研究  

Compatible Stability of Aminomethylbenzoic Acid Injection in Moxifloxacin Hydrochloride and Sodium Chloride Injection

作　　者：张丽梅[1] 沈静萍[1] 李俊[1] 

机构地区：[1]北京军区北戴河疗养院,河北秦皇岛066001

出　　处：《中国药业》2009年第3期7-8,共2页China Pharmaceuticals

摘　　要：目的考察盐酸氨甲苯酸注射液与盐酸莫西沙星氯化钠注射液配伍的稳定性。方法在25℃和37℃下8h内,采用紫外分光光度法测定氨甲苯酸(4.8mg/L)与莫西沙星(9.6mg/L)配伍后的含量,并测定pH值,观察外观、性状变化。结果两药配伍后8h内外观、pH值无明显变化,但在4h时氨甲苯酸的含量明显下降。结论盐酸莫西沙星氯化钠注射液与氨甲苯酸注射液在2h内可以配伍使用。Objective To study the compatibility of Aminomethylbenzoic Acid Injection in Moxifloxacin Hydrochloride and Sodium Chloride Injection. Methods At 25℃ and 37℃ within 8 h, the ultraviolet spectrophotometry was tised to study the change of content after the combination of aminomethylbenzoic acid （4.8 mg/L） and moxifloxacin （9.6 mg/L）. The change of the liquid appearance and its pH were observed. Results No significant change was seen in appearance and pH value after 8 h of mixing of the two agents. But after 4 h of mixing, the content of aminomethylbenzoic acid obviously dropped. Conclusion The compatibility of Aminomethylbenzoic Acid Injection with Moxifloxacin Hydrochloride and Sodium Chloride Injection can be used within 2 h.

关 键 词：氨甲苯酸 莫西沙星 配伍 稳定性 紫外分光光度法 

分 类 号：R969.2[医药卫生—药理学] R978.69[医药卫生—药学]