阿托伐他汀治疗高脂血症80例  

Clinical Observation on Atorvastatin in treatment of 80 cases with hyperlipidemia

作　　者：阳宇[1] 廖习清[1] 王大果[1] 

机构地区：[1]广东省深圳市第一人民医院,广东深圳518020

出　　处：《中国药业》2009年第3期47-48,共2页China Pharmaceuticals

摘　　要：目的观察阿托伐他汀治疗高脂血症的临床效果。方法对80例高血脂患者予晚上临睡前服阿托伐他汀,剂量20mg,共8周,观察用药前后血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平变化。结果治疗8周后,TC,TG,LDL-C较入组前分别下降了30%,28%,34%(P<0.01),HDL-C升高了12%(P<0.05),其中降低TC,TG,LDL-C及升高HDL-C的总有效率分别为92.50%,62.50%,95.00%,58.75%。治疗过程中除有6例丙氨酸氨基转移酶轻微升高、2例胃肠道不适外无其他不良反应发生。结论阿托伐他汀是一种安全、高效的高脂血症治疗药物。Objective To observe the efficacy of atorvastatin in the treatment of hyperlipidemia. Methods 80 cases with hyperlipidemia were given atorvastatin 20 mg/d before sleeping in the evening for 8 weeks. Before and after the treatment, the change of serum levels of TC, TG, HDL-C, LDL-C was examined and compared The difference was significant（P〈0.05）. Results After 8 weeks of treatment, serum TC, TG, LDL - C decreased by 30%, 28% and 34% respectively（ P 〈 0. 01 ）, serum HDL - C increased by 12% （ P 〈 0. 05）. The total effective rates of decreasing TC, TG, LDL - C and increasing HDL - C were 92. 50%, 62.50%, 95.00% and 58. 75%. in the treating course. No other adverse reactions occurred except 6 cases of slight GPT rise and 2 cases of gastrointestinal tract discomfort. Conclusion Atorvastatin is a safe and highly effective drug in treating hyperlipidemia.

关 键 词：阿托伐他汀 高脂血症 疗效 

分 类 号：R969.4[医药卫生—药理学] R972.6[医药卫生—药学]