噻氯匹啶对心绞痛患者血小板聚集的抑制作用及其意义  

The effect of ticlopidine on inhibition of platelet aggregationin angina pectoris and its clinical value

作　　者：徐军[1,2] 周春宁[1,2] 纵薇 诸葛海鸿[1,2] 

机构地区：[1]南京大学医学院临床学院 [2]南京军区南京总医院

出　　处：《南京大学学报（自然科学版）》1998年第2期214-217,共4页Journal of Nanjing University（Natural Science）

摘　　要：目的：比较噻氯匹啶和阿司匹林对心绞：噻氯匹啶对血小板聚集抑制的总有效率９４．４％，明显高于阿司匹林组（４０％），两组心绞痛发作的频次无显著差异。结论：噻氯匹啶可以有效地抑制心绞痛患者的血小板聚集，并可用于心绞痛的治疗。Objectives:To comparatively analyse the effect of ticlopidine and aspirin on the inhibition of platelet aggregatoin and their clinical value in patients of angina pectoris. Methods:ADP induced platelet aggregation was detected,and the daily times of the chest pain attacks was analyzed in two groups. Results:The effect of ticlopidine on plateler aggregation was stronger than that of aspirin (94.4% vs 40%),no statistical difference was observed in the daily frequency of the chest pain attakcs. Conclusions:Ticlopidine is a strong agent in the inhibition of platelet aggregation and may be an effective choice in the treatment of angina pectoris.

关 键 词：噻氯匹啶 心绞痛 阿司匹林 血小板 聚集 

分 类 号：R541.405[医药卫生—心血管疾病]