宫颈癌淋巴血管间隙浸润的临床病理评估  

The Clinicopathologic Evaluation of Lymph-Vascular Space Invasion Involvement in Cervical Cancer.

作　　者：陈莹莹[1] 郄明蓉[1] 万小丽[1] 张建[1] 侯敏敏[1] 王红静[1] 郑艾[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2009年第1期30-33,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

摘　　要：目的探讨宫颈淋巴血管间隙浸润(lymph-vascular space invasion,LVSI)与宫颈癌相关临床、病理因素的关系,为制定治疗方案、判断疾病预后提供依据。方法对2005年1月至2007年7月本院收治的546例宫颈鳞癌患者的临床资料进行回顾性分析。按照2003年国际妇产科联盟(InternationalFederation of Gynecology and Obstetrics,FIGO)标准对宫颈癌患者进行临床分组,对淋巴血管间隙浸润与其他临床、病理参数的关系进行χ2检验和Logistic回归分析(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准)。结果宫颈淋巴血管间隙浸润与宫颈癌类型、浸润深度、淋巴结转移、宫旁浸润有关;Logistic回归分析显示,宫颈淋巴血管间隙浸润与肿瘤类型、浸润深度和淋巴结转移相关。宫颈淋巴血管间隙浸润的发生率,随着手术病理学分期的升高而增加,两者呈正相关。结论宫颈淋巴血管间隙浸润是宫颈癌的重要预后风险因素;与淋巴结转移之间关系密切,可为判断疾病预后、制定治疗方案提供依据。Objective To analyze the relationship between lymph-vascular space invasion（LVSI） and the staging and histopathologic parameters of squamous cervical cancer, as well as its impact on the prognosis, in order to provide guidances for formulating treatment regimen and prognosis. Methods Retrospective analyse the clinic data of 546 patients with squamous carcinoma of cervix （SCC） who were treated in the Department of Gynecology and Obestetrics, West China Second University Hospital, Sichuan University from January 1, 2005 to July 31, 2007. The chi square test and Logistic regression were used to evaluate the relationship between lymph-vascular space invasion and other histopathologic parameters. Results Lymph-vascular space invasion appeared to have significant association with histological type, invasion depth, lymph-nodes metastasis and parametrial infiltration by the chi-square test. The factors associated with lymph-vascular space invasion were histological type, invasion depth and lymph-nodes metastasis by the Logistic regression. The incidence of lymph-vascular space invasion increased with the higher operative-histologic staging with statistic significance. Conclusion Lymph-vascular space invasion is an important prognostic factor for cervical cancer, and also can provide guidance for prognostic judgment and formulating treatment regimen.

关 键 词：宫颈鳞癌 淋巴血管间隙浸润 淋巴结转移 预后 

分 类 号：R737.33[医药卫生—肿瘤]