中药安体维康保肝降酶作用的动物实验和临床研究  

Experimental and Clinical Study on Liver-protecting and Enzyme-level-reducing Function of Antivirus Compound Capsule

作　　者：徐向田 张毅[2] 刘婷[2] 武桂兰[2] 秦彩玲[2] 

机构地区：[1]山东医学高等专科学校,临沂276002 [2]中国中医科学院中药研究所,北京100700

出　　处：《国际中医中药杂志》2009年第1期10-12,共3页International Journal of Traditional Chinese Medicine

基　　金：国家科技部创新基金资助项目（编号：01C26213700154）;志谢：参加本研究病理主要负责人：中国中医科学院中药研究所吴子伦副研究员;临床主要负责人：山东临沂市肝胆病医院李玉兰副主任医师;参加者：回连强主管技师、贺蓉研究实习员、刘瑞忠医师、王贤峰检验师等,在此一并致以衷心感谢.

摘　　要：目的观察安体维康对D-半乳糖胺（D—GlaN）所致急性肝损伤和慢性乙型肝炎的保肝降酶作用。方法给小鼠腹腔注射D-半乳糖胺800mg／kg造模，48h后血清转氨酶ALT和AST均明显升高；病理观察呈急性肝细胞损伤表现。临床观察采用配对分组法，分为慢性乙型肝炎治疗组60例，口服安体维康胶囊和水飞蓟素片；对照组57例，口服水飞蓟素片。两组均静滴甘利欣。结果①联苯双脂和安体维康1．6g、3．2g、6．4g／kg3个剂量组均能明显对抗血清AST水平的增高（P值分别〈0．001、〈0．01、〈0．01、〈0．001）；病理观察，安体维康3个剂量组均能明显减轻D-半乳糖胺所致小鼠肝组织病变程度（P〈0．01、〈0．05、〈0．01、〈0．01）。②慢性肝炎患者治疗3个月后，治疗组与对照组的ALT复常率分别是96．67％（58/60）、92．98％（53／57），无显著性差异（P〉0．02）；AST复常率分别为95％（57/60）、78．9％（45/57），有显著性差异（P〈0．01）；血清胆红素的复常率未见显著性差异。结论安体维康对D-半乳糖胺急性肝损伤小鼠和慢性乙型肝炎患者均具有明显的保护作用。Objective To observe the effect of Antivirus Compound Capsule in protecting liver and reducing enzyme level in chronic type B hepatitis and acute hepatic injury caused by D-GIaN. Methods Mice model was established by intraperitoneal injecting of D-GIaN 800mg/Kg. The level of ALT and AST was obviously increased after 48hours. Pathological test proved to be acute liver celt damage. Clinically 117 cases of chronic hepatitis B was recruited into a control group （57 cases） and a treatment group （60 cases）. The treatment group was treated with Antivirus Compound Capsule and Silymarin tablet, and the control group was treated with Silymarin tablet. Besides, both groups were infused with diammonium glycyrrhizinate in vein. Results （1）Three dosage levels of 1.6 g, 3.2 g and 6.4 g/kg of both Lianbenshuangzhi and Anlivirus Compound Capsule can obviously reduce level ofAST （P〈0.001, 〈0.01, 〈0.01, 〈0.001） ; Three dosage levels of Antivirus Compound Capsule can obviously reduce the degree hepatic pathological changes caused by D-GlaN induced（P〈0.01, 〈 0.05, 〈0.01, 〈0.01）. （1）There was no obvious difference of negative conversion rate of ALT （96.67%（58/60）and 95%（57/60） for the treatment group and the control group） between the two groups with P〉0.02, while there was obvious difference of negative conversion rate of AST. [92.98% （53/57） and 78.9% （45/57） for the treatment group and the control group] between the two groups with P〈0.01. Conclusion Antivirus Compound Capsule is effective in protecting liver and reducing enzyme level of patients with chronic hepatitis B and acute hepatic injury caused by D-GIaN.

关 键 词：安体维康胶囊 D-半乳糖胺(D—GlaN) 肝损伤 乙型肝炎 

分 类 号：R285.5[医药卫生—中药学] R512.62[医药卫生—中医学]