艾可合剂对大鼠非细菌性前列腺炎纤维增生和炎症浸润的影响  

Effect of Aike Mixture on Fibroplasia and Inflammatory Infiltration in Rats with Non-bacterial Prostatitis

作　　者：张敏建[1] 褚克丹[1] 程心玲[1] 潘旭东[1] 程宛钧[1] 史亚磊[1] 

机构地区：[1]福建中医学院附属人民医院,福州350004

出　　处：《中国中西医结合杂志》2009年第1期46-50,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：福建省自然科学基金资助项目(NO.C0440014)

摘　　要：目的评价艾可合剂对大鼠非细菌性前列腺炎的抗炎作用。方法用消痔灵注射液致大鼠慢性前列腺炎模型,将造模大鼠按体重分层随机分成7组:艾可合剂高、中、低剂量组,模型组,八正合剂组,前列腺汤组以及假手术组。各用药组分别用疏肝理气的艾可合剂(高、中、低剂量),活血化瘀的前列腺汤、清热利湿的八正合剂治疗,采用普通光镜及透射电镜观察各组实验大鼠前列腺的病理改变。结果各用药组在腺泡结构和数量、间质、抗纤维增生程度及炎细胞浸润程度方面较模型对照组均有改善,具有统计学意义(P<0.05或P<0.01);艾可合剂高剂量组在抑制纤维母细胞增生和炎细胞浸润方面与前列腺汤组和八正合剂组比较有明显优势(P<0.05或P<0.01)。结论疏肝理气的艾可合剂对大鼠前列腺炎的抗炎作用与清热利湿的八正合剂、活血化瘀的前列腺汤比较有明显的优势。Objective To assess the anti-inflammatory effect of Aike Mixture （AKM） on rats with nonbacterial prostatitis （NBP）. Methods Rat model of NBP was established by injection of Xiaozhiling Injection. The experimental rats were randomized into 7 groups, the three AKM groups （ A1 , A2 and A3 ）, treated with high, middle and low dose of AKM respectively, the 2 positive control groups （ C1 and C2 ）, treated by Bazheng Mixture （BZM） and Qianliexian Decoction （QLXD） respectively, the model control group （Cm） and the sham-operative control group （Cso）. The pathological changes in rats＇ prostate were observed by light microscope and transmission electron microscope. Results Significant differences in the number and structure of acini, mesenchyma, as well as the degrees of anti-fibroplasia and inflammatory cell infiltration were shown between the treated groups （A1, A2, A3, C1, C2） and the untreated groups （Cm, Cso）, with statistical significance （P〈0.05 or P〈 0.01 ）. However, the anti-fibroplasia and anti-inflammatory effects in A, were better than that in the two positive control groups significantly （ P 〈0.05 or P 〈0.01 ）. Conclusions AKM is a new TCM drug functioned for dispersing Gan-qi in treating NBP. It shows a better efficacy than that of BZM and QLXD, the two Chinese herbal medi- cines for clearing heat with remove dampness and activating blood circulation to remove stasis, respectively.

关 键 词：艾可合剂 前列腺炎 病理观察 

分 类 号：R285.5[医药卫生—中药学]