胡椒酸丁二醇单酯的合成及其降血脂作用研究  

Synthesis of a Butanediol Piperic Monoester and Its Anti-hyperlipidemia Activity

作　　者：宝贵荣[1,2] 博·格日勒图[1] 那日苏[1] 韩景芬[1] 昭日格图[1] 

机构地区：[1]内蒙古大学高分子化学及蒙药研究所,呼和浩特010021 [2]呼和浩特职业学院生物化学工程学院,呼和浩特010051

出　　处：《内蒙古大学学报（自然科学版）》2009年第1期52-55,共4页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学资助项目(No.30160103)

摘　　要：以蒙药药材荜茇为原料,经过分离、纯化得胡椒碱,进一步水解得胡椒酸.以胡椒酸和丁二醇为原料合成了胡椒酸丁二醇单酯,经13CNMR、1HNMR、UV、IR、EA表征后确证结构并做了一般药理实验,实验结果表明目标化合物具有良好的降血脂活性.Piperic acid was obtained by hydrolyzing Piperine that was extracted from seeds of Piper Longum L （Traditional medicine of Mongolian）. Using Piperic acid and butanediol as the raw materials to synthesize butanediol piperic monoester,and then the title compound was identified by the HPLC,^13 CNMR,^1 HNMR, UV, IR spectrum and elemental analysis. Pharmacological experiments showed that this compound had high anti-hyperlipidemia activity.

关 键 词：荜茇 降血脂作用 胡椒酸酯 胡椒碱 

分 类 号：P62[天文地球—地质矿产勘探]