血栓通注射液对大鼠血液流变学和兔眼球结膜微循环的影响  被引量:10

Effects of Xueshuantong Injection on Hemorheology in Rats and on Microcirculation of Bulbar Conjunctiva in Rabbits

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作  者:莫志贤[1] 罗超华[1] 

机构地区:[1]南方医科大学中医药学院,广州510515

出  处:《中国中医急症》2009年第2期258-260,共3页Journal of Emergency in Traditional Chinese Medicine

摘  要:目的研究血栓通注射液对大鼠血液流变学及兔眼球结膜微循环的影响。方法血栓通注射液分低、中、高三个剂量组,通过静脉注射给药;观测大鼠体内血栓形成、大鼠血液黏度、血浆黏度、红细胞压积、血小板聚集率以及兔眼球结膜微循环障碍模型血流状态和毛细血管交点数变化。结果血栓通注射液能抑制大鼠体内血栓形成,明显降低大鼠的血液黏度及红细胞压积,对大鼠血小板聚集也有显著的抑制作用。对高分子右旋糖酐引起的兔眼球结膜微循环障碍状态,血栓通有显著的改善作用,能加速血流,增加毛细血管开放数。结论血栓通注射液具有明显的活血化瘀作用。Objective: To study the effects of Xueshuantong Injection on hemorheology indices in rats and on microcirculation of bulbar conjunctiva in rabbits. Methods: Three dose groups of Xueshuantong Injection were designed and Xueshuantong was given by intravenous injection. The thrombogenesis, blood viscosity, plasma viscosity, hematocrit, platelet aggregation in rats and microcirculation of bulbar conjunctiva in rabbits were determined. Results: Xueshuan- tong Injection could inhibit rat thrombogenesis in vivo, significantly decrease blood viscosity and hematocrit, suppress platelet aggregation in rats and improve microcirculation disturbance of bulbar conjunctiva in rabbits. Conclusion: Xueshuantong Injection has marked actions of promoting blood circulation and relieving blood stasis.

关 键 词:血栓形成 血液黏度 血小板聚集 微循环 血栓通注射液 

分 类 号:R285.5[医药卫生—中药学]

 

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