叶酸、B族维生素对肺心病患者TXB_2和6-K-PGF1a的影响  

Influence of folic acid and B-vitamins on TXB_2 and 6-K-PGF1a in patients with pulmonary heart disease

作　　者：袁晓梅[1] 

机构地区：[1]河南省卫辉市新乡医学院一附院,453100

出　　处：《中国实用医药》2009年第3期44-45,共2页China Practical Medicine

摘　　要：目的了解叶酸、B族维生素对肺心病患者TXB2和6-K-PGF1的影响。方法对76例肺心病患者应用叶酸、B族维生素,治疗2周,采用放射免疫法测定治疗前后血浆TXB2和6-K-PGF1a水平。结果肺心病患者治疗后血浆TXB2明显下降(P<0.05),6-K-PGF1a明显升高(P<0.05)。结论应用叶酸、B族维生素可改善TXB2/6-K-PGF1a平衡,对治疗肺心病具有一定价值。Objective To study the mechanism of action of folic acid and B-vitamins in treatment of pulmonary heart disease （PHI）. Methods Radioimmuno assay were used to measure the levels of TXB2 and 6- K-PGF1. In serum of patients with PHD before and 2 weeks after using B-vitamins. Results The levels of TXB2 were significant decreased after two weeks dosing with folic acid and B-vitamins, but significant increasing in 6- K-PGFI（ P 〈 0.05）. Conclusion Application of folic acid and B-vitamin s will improve the ratio of TXB2 to 6- K-PGFla and confers some degree therapeutic and preventive value for PHD.

关 键 词：叶酸 B族维生素 血栓素B2 6-酮-前列腺素F1A 肺心病 肺动脉高压 

分 类 号：R541.5[医药卫生—心血管疾病]