胰岛素强化治疗老年早期糖尿病肾病的疗效  

Effect of insulin intensive treatment on early stage diabetic nephropathy in old patients.

作　　者：任晓军[1] 杨慧[1] 李汇[1] 崔景秋[1] 王瑜[1] 李鸿梅[1] 

机构地区：[1]天津医科大学总医院代谢科,300052

出　　处：《中国综合临床》2009年第1期75-77,共3页Clinical Medicine of China

摘　　要：目的观察胰岛素注射与口服降糖药物对老年早期糖尿病肾病尿蛋白的影响。方法116例老年早期糖尿病肾病患者随机分为A组（诺和锐及诺和灵N注射）、B组（诺和锐30注射）、C组（甘精胰岛素注射）和D组（口服格列奎酮），治疗12周。观察4组治疗前、后尿微量白蛋白排泄率（UAER）、糖化血红蛋白（HbA1c）、空腹血糖（FBG）、2h血糖（2hPG）。结果4组治疗后UAER、HbA。C、FBG、2hPG较治疗前均有下降，A、B、C治疗组疗效优于D组（P均〈0．05），A组疗效最好。结论胰岛素注射治疗对老年早期糖尿病肾病有显著疗效，并使血糖控制达标。Objective To observe the effects of injection of insulin and oral antidiabetic drug urine albumin in patients with early stage diabetic nephropathy （DN）. Methods 116 old patients suffering from early stage DN were randomly divided into 4 groups： group A（ treated with NovoRapid and Novolin N）, group B（ treated with NovoRapid 30）, group C （treated with insulin glargine） and group D （taking GlurenormTablets）. Urine albumin excretion rate （UAER）, glycosylated hemoglobin （HbA1 c）, fasting plasma glucose （FPG）, 2 hPG were detected in all patients before and after 12 weeks therapy. Results The levels of UAER,HbA1c,FBG,2 hPG decreased significantly in all patients of the four groups, especially in group A, B and C. Conclusion The insulin therapy can efficiently improve the diabetic nephropathy, and it is good for controlling blood glucose of the patients.

关 键 词：糖尿病肾病 胰岛素 尿微量白蛋白 

分 类 号：R587.1[医药卫生—内分泌]