短期鼻用皮质类固醇激素对儿童骨密度的影响  

Effect of short term using of intranasal steroids spray on bone mineral density in the children

作　　者：李哲 孟大为 马云鹏 赵方 吴玉杰 暴继敏 

机构地区：[1]辽宁省友谊医院耳鼻咽喉科,辽宁沈阳110015 [2]辽宁省金秋医院耳鼻咽喉科,辽宁沈阳110016 [3]辽宁省金秋医院骨外科,辽宁沈阳110016 [4]辽宁省金秋医院骨密度室,辽宁沈阳110016

出　　处：《中国耳鼻咽喉头颈外科》2009年第1期43-45,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金："十五"国家科技攻关项目(2004BA720A17);辽宁省自然基金项目(20042114);辽宁省科技计划项目(2004225003-19)联合资助

摘　　要：目的探讨短期鼻用皮质类固醇激素对儿童骨密度的影响。方法对28例5～8岁慢性鼻及鼻窦炎合并腺样体肥大的患儿,腺样体切除术后采用糠酸莫米松鼻喷雾剂,每日晨起给予100μg喷鼻,共5周,用双能X线骨密度仪监测治疗前和治疗后1年骨密度及Z评分。结果对治疗前和治疗后1年结果行统计分析,差异均无显著(P>0.05)。结论标准治疗剂量的鼻用皮质类固醇激素对儿童骨密度无明显影响。OBJECTIVE To investigate the effect of short term Using of intranasal steroids spray on bone mineral density in children. METHODS A one-year randomized study was conducted on the effect of short term using of intranasal steroids spray on bone mineral density in 28 children patient with chronic rhinitis- rhinosinusitis and enlarged adenoids. They all received adenoidectomy. The age of the 28 children ranged from 5 to 8 years old. After adenoidectomy, they used nasal spray Nasonex, 100 pg per day, for 5 weeks. BMD and Z-score was measured by dual energy X-ray absorptiometry at the beginning of treatment and 1 year after treatment. RESULTS There was no significant difference in bone mineral density before and after treatment （P〉0.05） . CONCLUSION Short term using of intranasal steroids spray in children didn＇t lead to osteoporosis if standard dose was given.

关 键 词：肾上腺皮质激素类 投药 鼻内 骨密度 儿童 

分 类 号：R765.4[医药卫生—耳鼻咽喉科] R766[医药卫生—临床医学]