加味厚朴温中汤对脾虚湿阻证大鼠血浆醛固酮及血清钠和钾离子的影响  

Effects of Jiaweihoupuwenzhong decoction on aldosterone and serum sodium,serum potassium in rats with syndrome of splenic asthenia and accumulation of dampness

作　　者：贺卫和[1] 陈晓阳[2] 邹志[3] 李云耀[2] 

机构地区：[1]湖南中医药大学药学院药理教研室,湖南长沙410007 [2]湖南中医药大学药学院中药教研室,湖南长沙410007 [3]湖南中医药大学

出　　处：《中国中西医结合消化杂志》2008年第6期359-361,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：湖南省自然科学基金资助项目(06JJ4032)

摘　　要：[目的]从水电解质的代谢和调节方面探讨加味厚朴温中汤治疗脾虚湿阻证大鼠的机制。[方法]建立脾虚湿阻证大鼠模型,按正常对照(正常)组、不造模给药组、模型组、自然恢复组、加味厚朴温中汤低、中、高剂量(低、中、高剂量)组7组,分别检测每组大鼠血浆醛固酮(ALD)以及血清Na+、K+浓度。[结果]与正常组比较,模型组ALD显著升高、K+显著降低(均P<0.01),血清Na+无明显变化;经加味厚朴温中汤治疗后,ALD显著下降、K+明显升高(均P<0.01),且比自然恢复组更迅速,Na+无显著性差异。不造模给药组与正常组比较,各指标差异均无统计学意义。[结论]脾虚湿阻证与水电解质代谢紊乱关系密切,加味厚朴温中汤治疗脾虚湿阻证的机制可能与其调节水电解质代谢有关。[Objective]To approach the mechanism of Jiaweihoupuwenzhong Decoction to heal the rats with syndrome of splenic asthenia and accumulation of dampness from the metabolism and accommodation of water-electrolyte. [Methods]The model of rats with syndrome of splenic asthenia and accumulation of dampness was established. The rats were divided into 7 groups： normal control, abbreviate control group given medication, model group, spontaneous recovery group, Jiaweihoupuwenzhong Decoction low, middle, high dose groups. Plasma aldosterone （ALD） and the serum sodium, serum potassium of every group were detected, [Results]Compared with normal control group, ALD of model group significantly increased（P〈0. 01）, serum potassium predominantly cut down（P〈0. 01）, serum sodium was almost no change. After the treatment of Jiaweihoupuwenzhong decoction, ALD was significantly lower than that in the model group（P〈0. 01）, serum potassium significantly increased（P〈0. 01）, and recovered more quickly than the controd,but serum sodium almost has no change; there was nosignificant difference of all the indexes between the control group given medication and normal group. [Conclusion ]There is close relationship between disorder of water-electrolyte metabolism and syndrome of splenic asthenia and accumulation of dampness, maybe accommodating the water-electrolyte metabolism was one of the mechanism of Jiaweihoupuwenzhong decoction to heal the rats with syndrome of splenic asthenia and accumulation of dampness.

关 键 词：加味厚朴温中汤 脾虚湿阻证 醛固酮 血清钠离子 血清钾离子 

分 类 号：R289.5[医药卫生—方剂学] R256.39[医药卫生—中药学]