定心胶囊对房颤大鼠血栓素B_2及基质金属蛋白酶9的影响  

Effect of Dingxin Capsule on TXB_2 and MMP-9 Level in Rats with Atrial Fibrillation

作　　者：张彦[1] 张艳[2] 杨硕[2] 宋婷婷[2] 礼海[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中国中医药信息杂志》2009年第2期26-27,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：辽宁省教育厅创新团队资助项目(2008T128)

摘　　要：目的观察定心胶囊对房颤大鼠血栓素B2(TXB2)、基质金属蛋白酶9(MMP-9)的影响,探讨其预防房颤的作用机理。方法采用氯化钙-乙酰胆碱混合液以鼠尾静脉给药的方式建立房颤的动物模型。筛选典型房颤心电图表现的大鼠,随机分为房颤模型组、定心胶囊治疗组、维拉帕米对照组及正常组。定心胶囊治疗组、维拉帕米对照组给药4周后,测定血清中TXB2、MMP-9的含量。结果定心胶囊治疗组与房颤模型组比较,血清中TXB2、MMP-9的含量明显降低,均P<0.05,差异有统计学意义;定心胶囊治疗组与西药对照组比较,房颤大鼠血清中TXB2、MMP-9的含量均降低,且定心胶囊治疗组优于西药对照组。结论定心胶囊能降低血清中TXB、MMP-9的含量,是防治房颤的有效药物。Objective To research the effect of Dingxin capsule on the level of TXB2 and MMP-9 in rats, and explore the mechanism of treating and preventing atrial fibrillation （AF） by TCM. Method AF animal model was established by injecting the calcium chloride-acetylcholine mixed liquid in coccygeal vein of rats The rats with typical ECG were divided randomly into 4 groups. AF model group （M-group）, Dingxin capsule group （D-group）, verapamil group （V-group）, normal group （N-group）. TXB2 and MMP-9 were measured 4 weeks later. Result Comparing with M-group, the level of TXB2 and MMP-9 of D-group decreased obviously （P〈0.05）. TXB2 and MMP-9 of both V-group and D-group decreased, while D-group was better, with statistical significance. Conclusion Dingxin capsule can reduce TXB2 and MMP-9 in serum, and is effective in treating and preventing atrial fibrillation.

关 键 词：定心胶囊 房颤 血栓素B2 基质金属蛋白酶9 大鼠 

分 类 号：R285.5[医药卫生—中药学]