甲亢方对甲状腺功能亢进模型大鼠甲状腺激素和甲状腺病理变化的影响  

Effect of Jiakang Formula on Thyroid Hormone and Thyroid Pathological Changes of Experimental Hyperthyroid Rats

作　　者：胡方林[1] 刘仙菊[1] 易法银[1] 阳春林[1] 龙玲[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中国中医药信息杂志》2009年第2期28-29,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省教育厅科研项目(05C362)

摘　　要：目的观察甲亢方对甲状腺功能亢进(以下简称"甲亢")模型大鼠甲状腺激素和甲状腺病理变化的影响。方法将50只大鼠随机分为正常组、甲亢模型组、甲亢方中剂量组、甲亢方高剂量组、西药对照组(每组10只),除正常组外,其余4组大鼠每日按75μg/100g体重灌服优甲乐(左甲状腺素钠)造成大鼠甲亢模型,不同剂量甲亢方内服,并与西药对照,21d后放免法测定血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)含量。结果甲亢方能降低甲亢大鼠血清T3、T4、FT3、FT4含量,提高血清TSH,以高剂量效果显著;能改善甲亢模型大鼠甲状腺组织病理变化,其中高剂量组甲状腺组织结构基本同正常组。结论甲亢方能够显著改善甲亢大鼠甲状腺功能和甲状腺组织病理变化。Objective To observe the effect of Jiakang formula on thyroid hormone and thyroid pathological changes of experimental hyperthyroid rats. Methods Forty rats were given Euthyrox dally at 75μg/100 gig and randomly divided into hyperthyroidism model group, control group, middle dose Jiakang formula group, high dose Jiakang formula group, each with 10 rats, as well as 10 rats as normal group. Three weeks later, the rats were killed for observing the effect of Jiakang formula on thyroid hormone and thyroid pathological changes of experimental hyperthyroid rats. Result Jiakang formula could lower the level of FT3, FT4, T3, T4 and promote the level of TSH, also improve thyroid pathological changes, especially in high dose Jiakang formula group. Conclusions Jiakang formula had the effect of improving the function and pathology of thyroid on experimental hyperthyroid rats.

关 键 词：甲状腺功能亢进症 甲亢方 甲状腺激素 甲状腺 大鼠 

分 类 号：R285.5[医药卫生—中药学]