绵羊PRNP遗传多样性与抗病育种研究进展  

Research progress on genetic diversity of sheep PRNP and resistance breeding

作　　者：管峰[1] 潘磊[1] 石国庆[2] 刘守仁[2] 杨利国[3] 

机构地区：[1]中国计量学院生命科学学院,杭州310018 [2]新疆兵团绵羊繁育生物技术重点实验室,石河子832000 [3]华中农业大学农业动物遗传育种与繁殖教育部重点试验室,武汉430070

出　　处：《遗传》2009年第2期137-141,共5页Hereditas（Beijing)

基　　金：国家高技术研究发展计划项目(863计划)(编号:2008AA101011);国家自然科学基金项目(编号:C120103)资助

摘　　要：朊蛋白(Prionprotein,PrP)是近年来被确认的引起人畜共患病的新型病原体,也是目前证明的具有自我复制和传播能力的蛋白质。PrP在多种动物体内表达并具有重要生理作用,其空间结构改变被认为是可传播性海绵状脑病(Transmissible spongiform encephalopathies,TSEs)的根源,研究发现朊蛋白编码基因(PRNP)遗传多样性与绵羊对瘙痒病的抗病性具有显著相关性。文章主要介绍了绵羊PRNP遗传多样性与痒病抗病性的关系以及PRNP遗传多样性对繁殖力和其他主要生产性能的影响等方面的研究成果,旨在为绵羊抗病育种研究提供理论参考。Prion protein （PrP） is a pathogeny identified in recent years, which infects both mankind and other mammals. It has been proved that PrP is a sole protein able to duplicate and propagate with itself. PrP can express in many tissues and has important physiological functions in many species of animals. The conformation change of PrP is the origin of transmissible spongiform encephalopathies （TSEs）. It has been proved that the sheep genetic diversity of prion protein gene （PRNP） is significantly associated with the resistance to scrapie. In this review, the evidence of association between polymorphisms of PRNP and resistance or susceptibility to scrapie and its effects on reproduction and performance traits were focused. The aim is to provide theory guidance for sheep breeding resistant to disease.

关 键 词：绵羊 PRNP 遗传多样性 抗病性 繁殖力 

分 类 号：S826[农业科学—畜牧学]