线粒体型硫氧还蛋白的研究进展  

Research Progress on Mitochondria-Located Thioredoxin

作　　者：陈燕[1] 常立文[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,武汉430030

出　　处：《实用儿科临床杂志》2009年第2期149-151,共3页Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金资助项目(30770944)

摘　　要：硫氧还蛋白是新近发现的一类小分子多功能蛋白,它与硫氧还蛋白还原酶及还原型辅酶Ⅱ共同组成了硫氧还蛋白系统。线粒体型硫氧还蛋白是硫氧还蛋白超家族中特异定位于线粒体的一员。目前研究显示,线粒体型硫氧还蛋白广泛参与体内细胞氧化应激反应、核酸代谢、细胞生长及凋亡等多种生物学过程,与机体生长发育、氧化应激损伤、肿瘤、器官缺血再灌注损伤等多种疾病相关。线粒体型硫氧还蛋白参与机体调节的具体机制,一方面是通过其分子内巯基/二硫键的相互转换来实现,另一方面是作为信号分子参与多种信号途径。The thioredoxin system consists of thioredoxin （Trx）,thioredoxin reductase（TrxR） and reduced nicotinamide adenine dinucleotide phosphate. Trx is a small redox - active multifunctional protein. Thioredoxin 2, which is locahzed in the matrix mitochondria, has been shown involved in not only oxidative stress,nucleic acid nletabolism,cell grow and apoptosis, but also many diseases such as organism growth and development,oxidative stress damage,cancer and ischemical reperfusion injury. It participates in redox reactions by reversible oxidation of its active center dithiol to disulfide and catalyzes dithio - disulfide exchange reactions involving many thiol - dependent processes. As signaling molecule,Trx2 participates in many signaling palhways.

关 键 词：硫氧还蛋白 线粒体 凋亡 

分 类 号：Q51[生物学—生物化学]