抗抑郁药历史与研究进展  

The History and Development of Antidepressants

作　　者：童晓欣[1] 童萼塘[2] 

机构地区：[1]北京大学深圳医院神经内科,518036 [2]华中科技大学同济医学院附属协和医院神经内科,武汉430022

出　　处：《医药导报》2009年第2期135-139,共5页Herald of Medicine

摘　　要：自20世纪50年代以来,抗抑郁药研究进展迅速。该文对抗抑郁药的历史分类、化学结构分类和作用机制分类等进行了简要介绍,并对新型抗抑郁药选择性5-羟色胺(5-HT)再摄取抑制药、5-HT再吸收促进药、选择性5-HT与去甲肾上腺素(NA)再摄取抑制药、去甲肾上腺素能和特异性5-HT能抑制药、去甲肾上腺素能和多巴胺能摄取抑制药、新型可逆性单胺氧化酶抑制药(MAO I)、新三环类抗抑郁药、天然与中草药抗抑郁药研究进展进行了较详细介绍。Objective Since the second half of the 20th century, there has been rapid development in the research of antidepressants. This paper presents a concise introduction of their historical, classification of chemical structure and action mechanism. It also gives a comprehensive introduction to the research development of new antipressants, including selective serotonin reuptake inhibitors （ SSRI ） , serotonin reuptake accelerant, selective serotonin and norepinephrine reuptake inhibitors （ SNRI ）, norepinephrine and special serotonin antidressant （NaSSA）, norepinephrine and dopamine reuptake inhibitors （NDRIs）, new reversible monoamine oxidase inhibitor, new tricyclic, nature and herbal antipressants.

关 键 词：抗抑郁药 抑郁症 5-羟色胺再摄取抑制药 选择性 5-羟色胺和去甲肾上腺素再摄取抑制药 选择性 单胺氧化酶抑制药 可逆性 

分 类 号：R971.4[医药卫生—药品]