SFE-CO2与渗漉法提取丹参药渣中脂溶性成分比较  

Comparison of Liposoluble Constituents Extracted by SFE-CO_2 and Percolation from Salvia Miltiorrhiza

作　　者：韩晓珂[1] 刘汉清[1] 张明[1] 马俊华 马继永 

机构地区：[1]南京中医药大学,210046 [2]山东华信制药有限公司,菏泽274009

出　　处：《医药导报》2009年第2期228-230,共3页Herald of Medicine

摘　　要：目的探寻大生产水提后丹参药渣中脂溶性成分的提取方法及其最佳工艺条件,以便对丹参药材进行综合利用。方法以丹参酮ⅡA的含量为指标,采用正交设计优选最佳提取工艺,并进行对比、验证。结果SFE-CO2萃取法的最佳工艺为:萃取压力35 MPa,夹带剂乙醇用量为100%,萃取温度40℃,萃取时间2 h,含量为3.87 mg。渗漉法最佳工艺为乙醇浓度95%,乙醇用量16倍,流速1 mL.min-1,药材目数20目,含量3.28 mg。结论SFE-CO2法优于渗漉法,并且提取含量高,丹参的综合利用完全可行。Objective To seek the optimal method and conditions for extracting liposoluble components from salvia mihiorrhiza, in order to develop comprehensive utilization of salvia mihiorrhiza. Methods The optimal extraction technology was chosen out by comparing and testing as contents of tanshinone Ⅱ A. Results The optimized conditions for SFE-CO2 extraction were as follows： pressure 35 MPa, 100% ethanol as modifier, the temperature 40 ℃, the operation time 2 h, with the content reached 3.87 mg· g^-1. The optimized conditions for Percolation were that 95% alcohol, 16-fold solvent amount, flow rate 1.0 mL · min^-1, 20 meshes drug powder, with the content reached 3.28 mg·g^-1 Conclusion SFE-CO2 is better than percolation with the higher extraction content, which shows that the comprehensive utilization of salvia mihiorrhiza could be feasible.

关 键 词：丹参 丹参酮ⅡA SFE—CO2 渗漉法 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]