吲哚美辛在单壁碳纳米管修饰电极上的电化学行为  

Electrochemical behavior of indomethacin at a single-wall carbon nanotube-modified electrode

作　　者：孔粉英[1] 曾冬铭[1] 徐茂田[1,2] 

机构地区：[1]中南大学化学化工学院生物传感所,长沙410083 [2]商丘师范学院化学系,商丘476000

出　　处：《分析试验室》2009年第2期38-41,共4页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(20775047);河南省自然科学基金(0511022300)项目资助

摘　　要：运用伏安法研究了吲哚美辛在单壁碳纳米管修饰电极上的电化学行为。在0.1mol/L HAc-NaAc缓冲溶液(pH4.5)中,吲哚美辛于0.91V(vs.SCE)电位处有一个峰形很好的氧化峰。与裸玻碳电极相比,吲哚美辛在修饰电极上的电位正移了约30mV,峰电流增加了近10倍,表明该修饰电极对吲哚美辛有较强的电催化作用。搅拌条件下开路富集2min,氧化峰电流与吲哚美辛在5.5×10-7～1.1×10-5mol/L浓度范围内呈良好的线性关系,检出限为1.1×10-7mol/L。该方法可用于药剂中吲哚美辛的分析。In this paper, the electrochemical behavior of indomethacin at a single-wall carbon nanotube （SWNT）-modified glassy carbon electrode is investigated by vohammetry. In a 0.1 mol/L HAc-NaAc buffer （pH 4.5）, indomethacin exhibits a sensitive oxidation peak at ca. 0.91 V （ vs. SCE）. Compared with the bare glassy carbon electrode, the potential shifts positively ca. 30 mV, and the current increases nearly 10 times. The results show that the modified electrode has a high eleetrocatalytic activity toward indomethacin. In a 2 min open-circuit accumulation with stirring, the oxidation peak current of indomethacin is linear with its concentration in the range of 5.5 × 10^-7 - 1.1 × 10^-5 mol/L and the detection limit is 1.1 × 10^-7mol/L. The proposed method is simple, rapid and sensitive, and can be used for the determination of indomethaein in pharmaceutical formulation.

关 键 词：单壁碳纳米管 吲哚美辛 修饰电极 伏安测定 

分 类 号：O657.1[理学—分析化学]