丙型肝炎病毒感染后慢性转化率的流行病学研究  

An Epidemiological Study on the Rate of Becoming Chronic in HCV Infection

作　　者：倪进发[1] 阚晓宏 毕鹏[1] 孙业桓[1] 章秋霞[2] 张庶民[3] 程慧[1] 黄守凯[1] 

机构地区：[1]安徽医科大学流行病学教研室,合肥230032 [2]安徽省立医院传染科 [3]中国药品生物制品检定所疫苗二室

出　　处：《中华流行病学杂志》1998年第3期144-146,共3页Chinese Journal of Epidemiology

基　　金：安徽省自然科学基金

摘　　要：笔者选择 1992～ 1996年间 ,安徽某乡“职业”供血员和 2所省级医院住院病人中 ,抗 -HCV( +)和 /或 HCV RNA( +)者为调查对象。追访了他们 HCV感染及其后的有关重要临床诊治和流行病学信息 ,同时调查了感染者的现况及相关实验室指标检测 ,描述了供血员人群丙型肝炎病毒感染后慢性转化率变化趋势。结果 HCV感染 6个月后慢性转化率为 55.93% ,1～ 4年慢性转化率依次为 50 %、4 8.54%、4 6.4 7%和 4 6.4 3%。表明其感染后慢性转化率一直持续高水平 ,下降缓慢 ,尤其 2年后基本稳定在 4 6%～ 4 8% ,远高于乙型肝炎 5%～ 10 %的慢性转化率。Anti- HCV( +) and/ or HCV RNA( +) were chosen for study on patients admitted to two provincial hospitals and“professional” blood donors in one of the areas in Anhui province in 1992 - 1996.Clinical diagnosis,treatment and epidemiology on HCV infection were retrospectively reviewed and in the meantime their present condition together with experimental data were studied;Chronic tendency on HCV infection of blood donors was described.Results showed that the rates of duration on becoming chronic for HCV infection were:six month later- 55.93% ,one year- 50 % ,two- years- 4 8.54% ,three years- 4 6.4 7% and four years- 4 6.4 3% .Rate of becoming chronic after HCV infection was continuously in high level,then slowly decreasing,to4 6% - 4 8% in two years,still much higher than hepatitis B which had a rate of 5% - 10 % becoming chronic.

关 键 词：丙型肝炎 慢性转化率 流行病学 

分 类 号：R512.63[医药卫生—内科学]